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肝移植术后成年患者并发症研究中的肝胆闪烁显像。经验描述。

Hepatobiliary scintigraphy in the study of complications in adult patients after liver transplant. Description of the experience.

作者信息

Vélez-Gutierrez C, Gutierrez-Villamil C, Arevalo-Leal S, Mejía-Hernandez G, Marín-Oyaga V

机构信息

Servicio de Medicina Nuclear, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Servicio de Cirugía y Transplantes, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia.

出版信息

Rev Esp Med Nucl Imagen Mol (Engl Ed). 2019 Jul-Aug;38(4):207-211. doi: 10.1016/j.remn.2019.02.006. Epub 2019 Apr 18.

Abstract

OBJECTIVE

To show the experience of the use of hepatobiliary scintigraphy in patients with suspected complications after liver transplantation in a high complexity centre.

MATERIAL AND METHOD

Retrospective, observational and descriptive study. All consecutive adult patients with liver transplantation between January 2013 and February 2018 were included, with one or more hepatobiliary scintigraphy during the early or late postoperative period. A total of 58 studies were analyzed in 38 patients (22 men and 16 women). Mean age: 48 years. In 34/38: cadaverous donor (89%), and in 4 (11%): a living donor. Demographic data and relevant information regarding the transplant were obtained, and the result was related to the surgical findings to determine the correlation between them. The influence of the test on the final clinical decisions was evaluated.

RESULTS

Findings: 9 scans (14%) were normal, 36 studies were negative, and 21 were positive for biliary complications. Of the total of 58 studies, 50 (86%) had impact on the clinical behaviour of observation or intervention. All the patients with findings of biliary complications (21/21; 100%) had clinical repercussion since 18/21 patients were taken to invasive studies or treatments, and 3/21 patients continued in medical management for findings of non-surgical biliary complications. In 14/18 patients taken to studies or procedures, correlation was found with the scintigraphic study. In 24/36 (66%) of patients with negative scintigraphy, an impact on clinical behaviour was found.

CONCLUSION

Hepatobiliary scintigraphy is a simple, non-invasive, reliable, current and available form for the early study of biliary complications in patients with liver transplantation. Important hepatocellular dysfunction should be taken into account as a frequent cause of false negative studies.

摘要

目的

展示在一个高复杂性中心对肝移植术后疑似并发症患者使用肝胆闪烁显像的经验。

材料与方法

回顾性、观察性和描述性研究。纳入2013年1月至2018年2月期间所有连续接受肝移植的成年患者,这些患者在术后早期或晚期进行了一次或多次肝胆闪烁显像。共分析了38例患者(22例男性和16例女性)的58项研究。平均年龄:48岁。38例中有34例(89%)为尸体供体,4例(11%)为活体供体。获取了人口统计学数据和有关移植的相关信息,并将结果与手术结果相关联以确定它们之间的相关性。评估了该检查对最终临床决策的影响。

结果

检查结果:9次扫描(14%)正常,36项研究为阴性,21项为胆道并发症阳性。在总共58项研究中,50项(86%)对观察或干预的临床行为有影响。所有有胆道并发症检查结果的患者(21/21;100%)都有临床反应,因为21例患者中有18例接受了侵入性检查或治疗,3例患者因非手术性胆道并发症的检查结果继续接受药物治疗。在接受检查或手术的18例患者中,14例与闪烁显像研究有相关性。在闪烁显像阴性的24/36(66%)患者中,发现对临床行为有影响。

结论

肝胆闪烁显像是一种简单、无创、可靠、当前可用的形式,用于肝移植患者胆道并发症的早期研究。应将重要的肝细胞功能障碍视为假阴性研究的常见原因。

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