静息态功能磁共振成像下昏迷患者的低频波动分数振幅与功能连接性

Fractional Amplitude of Low-Frequency Fluctuations and Functional Connectivity in Comatose Patients Subjected to Resting-State Functional Magnetic Resonance Imaging.

作者信息

Huang Lixuan, Zheng Yan, Zeng Zisan, Li Muyan, Zhang Ling, Gao Yang

机构信息

Department of Magnatic Resonance Imaging, The First People's Hospital of Nanning, Nanning, China.

Department of Magnatic Resonance Imaging, The First Affiliated Hospital of Henan University of TCM, Zhengzhou, China.

出版信息

Ann Indian Acad Neurol. 2019 Apr-Jun;22(2):203-209. doi: 10.4103/aian.AIAN_420_17.

DOI:10.4103/aian.AIAN_420_17

PMID:31007434

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6472252/

Abstract

OBJECTIVE

The objective of the study is to investigate the changes of fractional amplitude of low-frequency fluctuations (fALFFs) and functional connectivity (FC) in the brain function of comatose patients with resting-state blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD-fMRI) and to discuss the underlying neurophysiological mechanism of disease.

MATERIALS AND METHODS

Resting-state BOLD-fMRI scans were conducted on 20 comatose patients and 20 age-matched and gender-matched controls. The differences of fALFF between two groups were analyzed with two-sample -test; significant differences of connectivity between groups were acquired to calculate the FC of the precuneus with other brain regions.

RESULTS

Compared to the control group, the comatose patients exhibited a significant reduction in fALFF in various areas, including the right cingulate gyrus, left precuneus, right inferior parietal lobule, right superior parietal lobule, bilateral anterior/posterior central gyrus, middle frontal gyrus, right superior frontal gyrus, right superior temporal gyrus, and the bilateral cerebellar hemispheres ( < 0.05, Alphasim correction). Compared with controls, the brain region FC correlated with the precuneus reduced mainly located in the bilateral inferior parietal lobule, posterior central gyrus, lenticular nucleus, left anterior central gyrus, left medial frontal gyrus, left anterior lobe of the cerebellum, right insula, right transverse temporal gyri, and right thalamus. Regions whose FC increased include the left superior frontal gyrus, left side of the callosum, left superior parietal lobule, and both sides of the cingulate ( < 0.05, Alphasim correction).

CONCLUSION

Measurements of fALFF and FC obtained by resting-state BOLD-fMRI could provide considerable information for the analysis and evaluation of the brain function of comatose patients from the perspective of local function and global functional network and provide the theoretical basis for the study of coma nerve physiological mechanism.

摘要

目的

本研究旨在通过静息态血氧水平依赖性功能磁共振成像（BOLD-fMRI）探究昏迷患者脑功能中低频振幅分数（fALFF）及功能连接（FC）的变化，并探讨其潜在的神经生理机制。

材料与方法

对20例昏迷患者及20例年龄、性别匹配的对照者进行静息态BOLD-fMRI扫描。采用两样本t检验分析两组间fALFF的差异；获取组间连接性的显著差异以计算楔前叶与其他脑区的FC。

结果

与对照组相比，昏迷患者在多个区域的fALFF显著降低，包括右侧扣带回、左侧楔前叶、右侧顶下小叶、右侧顶上小叶、双侧中央前/后回、额中回、右侧额上回、右侧颞上回及双侧小脑半球（P<0.05，Alphasim校正）。与对照组相比，与楔前叶相关的脑区FC降低主要位于双侧顶下小叶、中央后回、豆状核、左侧中央前回、左侧额内侧回、左侧小脑前叶、右侧岛叶、右侧颞横回及右侧丘脑。FC增加的区域包括左侧额上回、胼胝体左侧、左侧顶上小叶及扣带回双侧（P<0.05，Alphasim校正）。