Zhu Y J, Ma G L, Song T B, Du L, Guo R C, Sun S L, Li H, Sun L G
Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
Zhonghua Yi Xue Za Zhi. 2017 Jul 18;97(27):2081-2086. doi: 10.3760/cma.j.issn.0376-2491.2017.27.001.
To analysis the change of brain functional activity in the left and right peripheral facial paralysis by using resting-state functional magnetic resonance imaging (R-fMRI) of fraction amplitude of low frequency fluctuation(fALFF) measurement technique, and research the abnormal brain region with different side patients whether there are differences. A total of 43 patients with peripheral facial paralysis patients (patient groups, divided into left / right two subgroups) and 21 healthy volunteers (control group) in this study.Resting-state fMRI were acquired for each volunteer and patient. The fALFF approach was used to compare the peripheral facial paralysis groups to healthy group.Functional analysis was performed with brain function analysis software REST and DPARSFA , and then analysis the difference of two groups of patients and control group in two sample test.At the same time, the correlation analysis between fALFF parameters map of the left and right side of two groups of patients and corresponding facial nerve grading TFGS score.Ultimately obtain a statistically significant brain regions. Compared to healthy group, the decreased fALFF areas in the left side facial paralysis were showed in the right superior temporal gyrus , the pole of the right temporal, right middle temporal gyrus, the left occipital gyrus, and left medial cingulate gyrus, left paracentral lobule, and the left supplementary motor area; while the increased brain regions have the right superior frontal gyrus, right middle frontal gyrus, the right precentral gyrus, bilateral inferior temporal gyrus and middle temporal gyrus.Compared to healthy group, the decreased fALFF areas in the right side facial paralysis were showed in the right inferior temporal gyrus and fusiform gyrus, the left inferior occipital gyrus, the left superior parietalgyrus, the left inferior parietalgyrus, left precuneus, left paracentral lobule, the left supplementary motor area; while the increased brain regions have the left Calcarine, right lingual gyrus, corpus callosum, right medial cingulum gyrus.In the left facial paralysis group TFGS score was positively correlated with brain regions have left middle frontal gyrus, left precuneus and left cuneus, while the negatively related brain area on the right lingual gyrus.In the right facial paralysis groups TFGS score was positively correlated with brain areas have right inferior temporal gyrus and middle temporal gyrus, left inferior parietalgyrus; while the negatively correlated brain area on the left superior temporal gyrus, the right medial frontal gyrus. The left and right side facial paralysis patient's mood and motor function integration mechanism may be different, and the patient's emotional and psychological changes may be associated with disease severity.
采用静息态功能磁共振成像（R-fMRI）低频振幅分数（fALFF）测量技术，分析左右侧周围性面瘫患者脑功能活动的变化，研究不同侧别患者脑区异常是否存在差异。本研究共纳入43例周围性面瘫患者（患者组，分为左/右两个亚组）和21名健康志愿者（对照组）。对每位志愿者和患者进行静息态功能磁共振成像扫描。采用fALFF方法比较周围性面瘫组与健康组。使用脑功能分析软件REST和DPARSFA进行功能分析，然后在两样本检验中分析两组患者与对照组的差异。同时，对两组患者左右侧fALFF参数图与相应面神经分级TFGS评分进行相关性分析。最终获得具有统计学意义的脑区。与健康组相比，左侧面瘫患者fALFF降低的脑区有右侧颞上回、右侧颞极、右侧颞中回、左侧枕叶、左侧内侧扣带回、左侧中央旁小叶和左侧辅助运动区；而脑区增加的有右侧额上回、右侧额中回、右侧中央前回、双侧颞下回和颞中回。与健康组相比，右侧面瘫患者fALFF降低的脑区有右侧颞下回和梭状回、左侧枕下回、左侧顶上小叶、左侧顶下小叶、左侧楔前叶、左侧中央旁小叶、左侧辅助运动区；而脑区增加的有左侧距状裂、右侧舌回、胼胝体、右侧内侧扣带回。在左侧面瘫组中，TFGS评分与左侧额中回、左侧楔前叶和左侧楔叶脑区呈正相关，而与右侧舌回脑区呈负相关。在右侧面瘫组中，TFGS评分与右侧颞下回和颞中回、左侧顶下小叶脑区呈正相关；而与左侧颞上回、右侧额内侧回脑区呈负相关。左右侧面瘫患者的情绪与运动功能整合机制可能不同，患者的情绪和心理变化可能与疾病严重程度相关。
