Luo Jiancheng, Zhang Baofang, Yvon Carine, Hutin Marie, Gerislioglu Selim, Wesdemiotis Chrys, Cronin Leroy, Liu Tianbo
Department of Polymer Science University of Akron 44325 Akron OH USA.
WEST Chem School of Chemistry University of Glasgow University Avenue G12 8QQ Glasgow UK.
Eur J Inorg Chem. 2019 Jan 31;2019(3-4):380-386. doi: 10.1002/ejic.201800158. Epub 2018 May 14.
Incorporating the building blocks of nature (e.g., peptides and DNA) into inorganic polyoxometalate (POM) clusters is a promising approach to improve the compatibilities of POMs in biological fields. To extend their biological applications, it is necessary to understand the importance of different non-covalent interactions during self-organization. A series of Anderson POM-peptide hybrids have been used as a simple model to demonstrate the role of different interactions in POM-peptide (biomolecules) systems. Regardless of peptide chain length, these hybrids follow similar solution behaviors, forming hollow, spherical supramolecular structures in acetonitrile/water mixed solvents. The incorporation of peptide tails introduces interesting stimuli-responsive properties to temperature, hybrid concentration, solvent polarity and ionic strength. Unlike the typical bilayer amphiphilic vesicles, they are found to follow the blackberry-type assemblies of hydrophilic macroions, which are regulated by electrostatic interaction and hydrogen bonding. The formation of electrostatic assemblies before the supramolecular formation is confirmed by ion-mobility mass spectrometry (IMS-MS).
将天然构建模块（如肽和DNA）融入无机多金属氧酸盐（POM）簇中，是提高POM在生物领域兼容性的一种很有前景的方法。为了扩展其生物学应用，有必要了解自组装过程中不同非共价相互作用的重要性。一系列Anderson POM-肽杂化物已被用作一个简单模型，以证明不同相互作用在POM-肽（生物分子）体系中的作用。无论肽链长度如何，这些杂化物都表现出相似的溶液行为，在乙腈/水混合溶剂中形成空心球形超分子结构。肽尾的引入为温度、杂化物浓度、溶剂极性和离子强度带来了有趣的刺激响应特性。与典型的双层两亲性囊泡不同，它们被发现遵循亲水性大离子的黑莓型组装，这种组装受静电相互作用和氢键调节。离子淌度质谱（IMS-MS）证实了在超分子形成之前静电组装体的形成。
