• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.

作者信息

DeVries V G, Schaffer S A, Largis E E, Dutia M D, Wang C H, Bloom J D, Katocs A S

出版信息

J Med Chem. 1986 Jul;29(7):1131-3. doi: 10.1021/jm00157a002.

DOI:10.1021/jm00157a002
PMID:3100794
Abstract
摘要

相似文献

1
Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity.潜在的抗动脉粥样硬化药物。5. 一种具有降胆固醇活性的酰基辅酶A：胆固醇O-酰基转移酶抑制剂。
J Med Chem. 1986 Jul;29(7):1131-3. doi: 10.1021/jm00157a002.
2
Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2.一系列与4-苯基咪唑相连的苯基脲的构效关系。具有抗动脉粥样硬化活性的新型强效酰基辅酶A：胆固醇O-酰基转移酶抑制剂。2.
J Med Chem. 1993 May 28;36(11):1641-53. doi: 10.1021/jm00063a014.
3
Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity.N-[2-(二甲基氨基)-6-[3-(5-甲基-4-苯基-1H-咪唑-1-基)丙氧基]苯基]-N'-戊基脲及其类似物的构效关系。具有抗动脉粥样硬化活性的新型强效酰基辅酶A：胆固醇O-酰基转移酶抑制剂。
J Med Chem. 1993 May 28;36(11):1630-40. doi: 10.1021/jm00063a013.
4
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.
J Med Chem. 1994 Mar 4;37(5):560-2. doi: 10.1021/jm00031a002.
5
Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives.新型酰基辅酶A：胆固醇酰基转移酶抑制剂。3-喹啉基脲衍生物的合成及生物活性
J Med Chem. 1994 Jun 24;37(13):2079-84. doi: 10.1021/jm00039a020.
6
TMP-153, a novel ACAT inhibitor, lowers plasma cholesterol through its hepatic action in golden hamsters.新型酰基辅酶A胆固醇酰基转移酶抑制剂TMP - 153通过其在金黄仓鼠肝脏中的作用降低血浆胆固醇。
Atherosclerosis. 1995 Nov;118(1):145-53. doi: 10.1016/0021-9150(95)05601-r.
7
Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂。7. 一系列具有增强降胆固醇活性的取代N-苯基-N'-[(1-苯基环戊基)甲基]脲的研发。
J Med Chem. 1994 May 27;37(11):1652-9. doi: 10.1021/jm00037a016.
8
Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogues.潜在的抗动脉粥样硬化药物。6. 降胆固醇三取代脲类似物。
J Med Chem. 1989 Oct;32(10):2318-25. doi: 10.1021/jm00130a016.
9
CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.
J Lipid Res. 1989 May;30(5):681-90.
10
TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.新型酰基辅酶A：胆固醇酰基转移酶1抑制剂TMP - 153可抑制大鼠和仓鼠的胆固醇吸收并降低其血浆胆固醇水平。
Atherosclerosis. 1995 Feb;113(1):71-8. doi: 10.1016/0021-9150(94)05429-m.