成纤维细胞生长因子23的合成与活性。
FGF23 Synthesis and Activity.
作者信息
Noonan Megan L, White Kenneth E
机构信息
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Curr Mol Biol Rep. 2019 Mar;5(1):18-25. doi: 10.1007/s40610-019-0111-8. Epub 2019 Jan 17.
PURPOSE OF REVIEW
The phosphaturic hormone FGF23 is produced primarily in osteoblasts/osteocytes and is known to respond to increases in serum phosphate and 1,25(OH) vitamin D (1,25D). Novel regulators of FGF23 were recently identified, and may help explain the pathophysiologies of several diseases. This review will focus on recent studies examining the synthesis and actions of FGF23.
RECENT FINDINGS
The synthesis of FGF23 in response to 1,25D is similar to other steroid hormone targets, but the cellular responses to phosphate remain largely unknown. The activity of intracellular processing genes control FGF23 glycosylation and phosphorylation, providing critical functions in determining the serum levels of bioactive FGF23. The actions of FGF23 largely occur through its co-receptor αKlotho (KL) under normal circumstances, but FGF23 has KL-independent activity during situations of high concentrations.
SUMMARY
Recent work regarding FGF23 synthesis and bioactivity, as well as considerations for diseases of altered phosphate balance will be reviewed.
综述目的
磷调节激素FGF23主要由成骨细胞/骨细胞产生，已知其对血清磷酸盐和1,25(OH)维生素D（1,25D）升高有反应。最近发现了FGF23的新型调节因子，这可能有助于解释几种疾病的病理生理学。本综述将聚焦于近期研究FGF23合成及作用的相关内容。
最新发现
FGF23对1,25D的合成与其他类固醇激素靶点相似，但细胞对磷酸盐的反应仍知之甚少。细胞内加工基因的活性控制FGF23的糖基化和磷酸化，在决定生物活性FGF23的血清水平方面发挥关键作用。正常情况下，FGF23的作用主要通过其共受体α-klotho（KL）介导，但在高浓度情况下FGF23具有不依赖KL的活性。
总结
将对近期有关FGF23合成及生物活性的研究以及磷酸盐平衡改变相关疾病的考量进行综述。
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