Papastergiou Eleni, Rallis Dimitrios, Papagianni Afroditi, Cholevas Vasileios, Katzilakis Nikolaos, Siomou Ekaterini, Stiakaki Eftichia, Makis Alexandros
Department of Pediatrics, University Hospital of Ioannina, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
Department of Pediatric Hematology-Oncology, University Hospital of Heraklion, Postgraduate Program "Hematology-Oncology in Childhood and Adolescence" of Medical School, University of Crete, 71003 Heraklion, Greece.
Biology (Basel). 2024 Sep 17;13(9):728. doi: 10.3390/biology13090728.
We intend to evaluate the association of intact Fibroblast Growth Factor 23 (i-FGF23), a phosphaturic hormone that contributes to anemia of inflammation, with markers of iron homeostasis, inflammation, and bone mineral metabolism in acute pediatric infections. Seventy-nine children, aged 1 month-13 years, out of which forty-two were males and thirty-seven females, participated in this study. Children with diseases and nutrient deficiencies causing anemia were excluded. Twenty-six patients had bacterial infections, twenty-six had viral infections, and twenty-seven children served as healthy controls. Complete blood count, markers of inflammation, iron and mineral metabolism, serum hepcidin, and i-FGF23 were compared between the groups. Thirty-nine percent of patients with bacterial infection and twelve percent of patients with viral infection presented characteristics of anemia of inflammation ( < 0.001). Ninety-two percent of patients with bacterial infection and eighty-one percent of patients with viral infection had functional iron deficiency ( < 0.001). Hepcidin was significantly positively correlated with the duration of fever, markers of inflammation, and negatively with iron, mineral metabolism parameters, and i-FGF23. i-FGF23 was positively correlated with iron metabolism parameters and negatively with the duration of fever, markers of inflammation, and hepcidin. Hepcidin levels increase, whereas i-FGF23 levels decrease in acute pediatric infections. Further research is required to understand the role of FGF23 in the hepcidin-ferroportin axis and for hepcidin in the diagnosis of bacterial infections and mineral metabolism.
我们旨在评估完整的成纤维细胞生长因子23（i-FGF23）（一种导致炎症性贫血的排磷激素）与急性儿科感染中铁稳态、炎症和骨矿物质代谢标志物之间的关联。79名年龄在1个月至13岁之间的儿童参与了本研究，其中42名男性，37名女性。患有导致贫血的疾病和营养缺乏的儿童被排除在外。26例患者患有细菌感染，26例患有病毒感染，27名儿童作为健康对照。对各组之间的全血细胞计数、炎症标志物、铁和矿物质代谢、血清铁调素和i-FGF23进行了比较。39%的细菌感染患者和12%的病毒感染患者表现出炎症性贫血的特征（<0.001）。92%的细菌感染患者和81%的病毒感染患者存在功能性缺铁（<0.001）。铁调素与发热持续时间、炎症标志物呈显著正相关，与铁、矿物质代谢参数和i-FGF23呈负相关。i-FGF23与铁代谢参数呈正相关，与发热持续时间、炎症标志物和铁调素呈负相关。在急性儿科感染中，铁调素水平升高，而i-FGF23水平降低。需要进一步研究以了解FGF23在铁调素-铁转运蛋白轴中的作用以及铁调素在细菌感染诊断和矿物质代谢中的作用。
