三维打印抗菌及显影性结构
Three-Dimensional Printing Antimicrobial and Radiopaque Constructs.
作者信息
Boyer Christen J, Ballard David H, Weisman Jeffery A, Hurst Spencer, McGee David J, Mills David K, Woerner Jennifer E, Jammalamadaka Uday, Tappa Karthik, Alexander J Steven
机构信息
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Department of Oral and Maxillofacial Surgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
出版信息
3D Print Addit Manuf. 2018 Mar;5(1):29-35. doi: 10.1089/3dp.2017.0099. Epub 2018 Mar 1.
Three-dimensional (3D) printing holds tremendous potential as a tool for patient-specific devices. This proof-of- concept study demonstrated the feasibility, antimicrobial properties, and computed tomography(CT) imaging characteristics of iodine/polyvinyl alcohol (PVA) 3D meshes and stents. Under scanning electron microscopy, cross-linked PVA displays smoother and more compacted filament arrangements. X-ray and transaxial CT images of iodized PVA vascular stents show excellent visibility and significantly higher Hounsfield units of radiopacity than control prints. Three-dimensional PVA prints stabilized by glutaraldehyde cross-linking and loaded with iodine through sublimation significantly suppressed Escherichia coli and Staphylococcus aureus growth in human blood agar disk diffusion assays. It is suggested that PVA 3D printing with iodine represents an important new synthetic platform for generating a wide variety of antimicrobial and high-visibility devices.
三维（3D）打印作为一种制造个性化医疗设备的工具具有巨大潜力。这项概念验证研究展示了碘/聚乙烯醇（PVA）3D网格和支架的可行性、抗菌性能以及计算机断层扫描（CT）成像特征。在扫描电子显微镜下，交联的PVA显示出更光滑、更紧密的细丝排列。碘化PVA血管支架的X射线和横断面CT图像显示出极佳的可视性，并且其射线不透性的亨氏单位显著高于对照打印件。通过戊二醛交联稳定并通过升华加载碘的三维PVA打印件在人血琼脂平板扩散试验中显著抑制了大肠杆菌和金黄色葡萄球菌的生长。研究表明，含碘的PVA 3D打印代表了一个重要的新型合成平台，可用于制造各种抗菌且具有高可视性的设备。
Zotero 插件