Fujita Hikaru, Terasaki Hiromitsu, Kakuyama Satoshi, Hioki Kazuhito, Kunishima Munetaka
Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences , Kanazawa University , Kakuma-machi, Kanazawa 920-1192 , Japan.
Faculty of Pharmaceutical Sciences , Kobe Gakuin University , 1-1-3 Minatojima , Chuo-ku, Kobe 650-8586 , Japan.
Org Lett. 2019 May 3;21(9):3093-3097. doi: 10.1021/acs.orglett.9b00732. Epub 2019 Apr 22.
A new triazinone-based reagent for O- p-methoxybenzylation has been developed. In spite of its stability in solid form, this reagent converts a free alcohol into the corresponding p-methoxybenzyl ether with mild heating (50-60 °C) in a solution. High functional group tolerance can be achieved because the reaction does not require the addition of an acidic or basic activator.
一种用于O-对甲氧基苄基化的新型三嗪酮基试剂已被开发出来。尽管该试剂在固体形式下很稳定,但在溶液中经温和加热(50-60°C)就能将游离醇转化为相应的对甲氧基苄基醚。由于该反应不需要添加酸性或碱性活化剂,因此可以实现高官能团耐受性。