基于三嗪的可分离且稳定的环氧化试剂：三唑氧。
An Isolable and Bench-Stable Epoxidizing Reagent Based on Triazine: Triazox.
机构信息
Faculty of Pharmaceutical Sciences , Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University , Kakuma-machi, Kanazawa 920-1192 , Japan.
Faculty of Pharmaceutical Sciences , Kobe Gakuin University , 1-1-3 Minatojima , Chuo-ku, Kobe 655-8586 , Japan.
出版信息
Org Lett. 2018 Apr 6;20(7):2015-2019. doi: 10.1021/acs.orglett.8b00560. Epub 2018 Mar 23.
A new triazine-based oxidizing reagent, 2-hydroperoxy-4,6-diphenyl-1,3,5-triazine (Triazox), has been developed. The reagent can be synthesized from inexpensive starting materials and is a bench-stable solid that is isolable in pure form. Epoxidation of alkenes possessing acid-sensitive functionalities using Triazox proceeded in good to excellent yields. The accompanying nonacidic triazinone coproduct can be easily removed by filtration. These features indicate that Triazox is a practically useful oxidizing reagent.
一种新型的三嗪基氧化试剂 2-过氧-4,6-二苯基-1,3,5-三嗪（Triazox）已经被开发出来。该试剂可以用廉价的起始原料合成，是一种稳定的固体，可纯品形式分离得到。具有酸敏感官能团的烯烃用 Triazox 进行环氧化反应，产率良好至优秀。伴随的非酸性三嗪酮副产物可以通过过滤轻易去除。这些特点表明 Triazox 是一种非常实用的氧化试剂。
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