富血小板血浆和纤维蛋白胶自体移植减少单纯切除一期缝合治疗藏毛窦术后疼痛。
Autologous Platelet-Rich Plasma and Fibrin Glue Decrease Pain Following Excision and Primary Closure of Pilonidal Sinus.
机构信息
In the Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Daryoush Hamidi Alamdari, PhD, is Associate Professor of Biochemistry; Mohamad Reza Motie, MD, is Associate Professor of Surgery; Nasim Kamalahmadi, MD, is a Medical Practitioner; and Mohsen Aliakbarian, MD, is Associate Professor of Surgery. Acknowledgments: The authors thank the patients who participated in the study and Ms M. Hassanpour for editing the manuscript. The study was supported by the Vice Chancellor for Research of Mashhad University of Medical Sciences (grant 88529). The authors have disclosed no other financial relationships related to this article. Submitted April 24, 2018; accepted in revised form June 8, 2018.
出版信息
Adv Skin Wound Care. 2019 May;32(5):234-237. doi: 10.1097/01.ASW.0000550589.23921.45.
BACKGROUND
Pilonidal sinus is one of the most complicated chronic wounds common in younger adults. This disabling condition affects the natal clefts of the buttocks and often requires surgery.
OBJECTIVE
To investigate the effect of autologous platelet-rich plasma and fibrin glue (PRP-FG) on pain reduction and the healing process of pilonidal sinus after excisional surgery with primary closure.
METHODS
This randomized clinical trial study included 40 patients with pilonidal sinus admitted to a surgical ward. Patients were randomly divided into two groups: the control group, who underwent wide excision of the sinus with primary closure, and the case group, who had wide excision of the sinus with primary closure along with injection of autologous PRP-FG into the wound. For 6 months, patients were followed up for their severity of pain, wound healing process, the time it took them to get back to normal activities, infection, and other complications.
RESULTS
In the first and second week after surgery, the severity of pain in the case group was reduced significantly in comparison with the control group. Healing time decreased but not significantly. There was no significant difference in infection and recurrence between the two groups.
CONCLUSIONS
The addition of PRP-FG has the potential to reduce pain significantly in primary closure of pilonidal sinus.
背景
藏毛窦是年轻人中最常见的一种复杂慢性伤口。这种使人丧失能力的疾病会影响臀部的会阴裂隙，并且常常需要手术治疗。
目的
研究富血小板纤维蛋白（PRP-FG）在切除并一期缝合术后减轻疼痛和促进藏毛窦愈合中的作用。
方法
这是一项随机临床试验研究，共纳入 40 名患有藏毛窦的患者，这些患者被分配到对照组（接受广泛切除窦道并一期缝合）和病例组（接受广泛切除窦道并一期缝合联合注射自体 PRP-FG 到伤口）。在 6 个月的时间里，对患者的疼痛严重程度、伤口愈合过程、恢复正常活动的时间、感染和其他并发症进行随访。
结果
与对照组相比，病例组在术后第 1 和第 2 周的疼痛严重程度显著降低。愈合时间虽有所减少，但无统计学意义。两组之间在感染和复发方面无显著差异。
结论
在一期缝合治疗藏毛窦时，添加 PRP-FG 有可能显著减轻疼痛。
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