Department of Orthodontics, School of Health Sciences, Faculty of Dentistry, Aristotle University of Thessaloniki, Greece.
Department of Training and Operations, Military Hospital of Thessaloniki, Greece.
Eur J Orthod. 2020 Jan 27;42(1):60-71. doi: 10.1093/ejo/cjz021.
Bisphosphonates are a class of drugs prescribed for several osseous related disorders owing to their ability to regulate bone turnover, which could in turn affect orthodontic treatment outcomes.
To examine the effect of bisphosphonate (BP) use on orthodontic patients through clinical and radiographic measurements.
Systematic and unrestricted search of 17 databases complemented with additional hand-searches were performed up to March 2019.
Articles reporting on human patients with a history of BPs administration that received orthodontic treatment were eligible for inclusion.
Data regarding the medical profile of the patients, the specific type of malocclusion and the performed treatment plan, as well as the clinical and radiographic outcomes were extracted. Quality assessment was performed by the ROBINS-I tool for the cohort studies and by a slightly modified checklist from the original one proposed by Agbabiaka et al. for the case reports.
7 articles (1 retrospective cohort study and 6 case reports) were eventually included in the present review including 122 subjects (29 patients and 93 controls) reporting on the clinical and radiographic changes following orthodontic treatment of patients during or after BPs use. BPs seem to have a controversial effect on the clinical and patient-reported variables, even though the majority of the included patients presented with compromised treatment results and a rather slow rate of tooth movement. Most radiographic findings revealed mild root resorption, widened periodontal ligament spaces and sclerotic changes on the surrounding alveolar bone. However, these results should be interpreted with caution, due to the limited number of the eligible articles and their limitations.
The included studies were of rather low quality due to study design and incomplete reporting.
BP administration seems to be associated with compromised clinical outcomes, prolonged treatment time, and moderate changes on the roots and surrounding tissues of orthodontic patients.
Non-registered.
None.
双膦酸盐类药物因其调节骨转换的能力而被用于治疗多种与骨骼相关的疾病，这反过来可能会影响正畸治疗的结果。
通过临床和影像学测量检查双膦酸盐（BP）使用对正畸患者的影响。
系统和无限制地检索了 17 个数据库，并辅以额外的手工检索，检索时间截至 2019 年 3 月。
报告有 BP 给药史并接受正畸治疗的人类患者的文章符合纳入标准。
提取有关患者的医疗概况、特定类型的错颌畸形和所进行的治疗计划以及临床和影像学结果的数据。使用 ROBINS-I 工具对队列研究进行质量评估，并使用 Agbabiaka 等人提出的原始清单稍作修改对病例报告进行质量评估。
本综述最终纳入了 7 篇文章（1 项回顾性队列研究和 6 项病例报告），共纳入 122 名患者（29 名患者和 93 名对照），报告了 BP 使用期间或之后接受正畸治疗的患者的临床和影像学变化。BP 似乎对临床和患者报告的变量有争议的影响，尽管大多数纳入的患者的治疗结果受损，牙齿移动的速度也较慢。大多数影像学发现显示轻度根吸收、牙周韧带间隙增宽和周围牙槽骨的硬化性变化。然而，由于合格文章数量有限且存在局限性，这些结果应谨慎解释。
由于研究设计和报告不完整，纳入的研究质量较低。
BP 给药似乎与临床结果受损、治疗时间延长以及正畸患者的根和周围组织发生中度变化有关。
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