Tisovic Kelly, Amezcua Lilyana
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Biomedicines. 2019 Apr 19;7(2):32. doi: 10.3390/biomedicines7020032.
Multiple sclerosis (MS) primarily affects women in childbearing age and is associated with an increased risk of adverse post-partum outcomes. Relapses and now fetal exposure to disease modifying treatments in the early phase of pregnancy and thereafter are of concern. Safe and effective contraception is required for women who wish to delay or avoid pregnancy while on disease-modifying treatments. Counseling and planning is essential to assess the risk of both fetal and maternal complications, particularly now in the era of highly efficient and riskier therapies. The purpose of this review is to provide a practical framework using the available data surrounding pregnancy in MS with the goal of optimizing outcomes during this phase in MS.
多发性硬化症（MS）主要影响育龄女性，并与产后不良结局风险增加相关。复发以及目前孕期早期及之后胎儿暴露于疾病修正治疗均令人担忧。对于希望在接受疾病修正治疗期间推迟或避免怀孕的女性，需要安全有效的避孕措施。咨询和规划对于评估胎儿和母亲并发症的风险至关重要，尤其是在高效且风险更高的治疗时代。本综述的目的是利用围绕MS患者妊娠的现有数据提供一个实用框架，目标是优化MS患者在此阶段的结局。
