Department of Pathology, Oregon Health & Science University, Portland, Oregon, USA.
Kidney Int. 2019 May;95(5):1025-1026. doi: 10.1016/j.kint.2019.01.034.
DnaJ homolog subfamily B member 9 (DNAJB9) is a sensitive and specific marker of fibrillary glomerulonephritis (FGN) in kidney biopsies. In this issue, Nasr and Dasari et al. demonstrate significantly elevated concentrations of DNAJB9 in serum from patients with FGN. This advances our understanding of DNAJB9 as a biomarker in FGN and reframes questions about pathogenesis and potential clinical applications of DNAJB9 serum testing.
DNAJ 同源物亚家族 B 成员 9（DNAJB9）是肾脏活检中纤维状肾小球肾炎（FGN）的敏感和特异性标志物。在本期中，Nasr 和 Dasari 等人证明了 FGN 患者血清中 DNAJB9 的浓度显著升高。这加深了我们对 DNAJB9 作为 FGN 生物标志物的理解，并重新提出了有关 DNAJB9 血清检测的发病机制和潜在临床应用的问题。
