Faculty of Health and Nutrition, Shubun University, Ichinomiya, Aichi 491-0938, Japan.
Med Hypotheses. 2019 May;126:66-68. doi: 10.1016/j.mehy.2019.03.017. Epub 2019 Mar 22.
Narcolepsy with cataplexy is a lifelong sleep disorder associated with orexin/hypocretin deficiency in the central nervous system. In addition to a genetic predisposition, a variety of environmental factors, such as influenza viruses, have been implicated in the pathogenesis of the disease. In this article, a hypothesis is proposed that environmental agents access the olfactory bulb and trigger neuroinflammation, which in turn induces neurodegeneration of orexinergic neurons in the lateral hypothalamus and other neuronal subpopulations regulating the sleep-wake cycle, which triggers the development of narcolepsy.
发作性睡病伴猝倒症是一种终身性睡眠障碍，与中枢神经系统中食欲素/下丘脑分泌素缺乏有关。除了遗传易感性之外，多种环境因素，如流感病毒，也与疾病的发病机制有关。本文提出了一个假说，即环境因子进入嗅球并引发神经炎症，进而导致外侧下丘脑的食欲素能神经元和调节睡眠-觉醒周期的其他神经元亚群发生神经退行性变，从而引发发作性睡病的发生。
