Department of Translational Neuroscience, Cajal Institute, Spanish National Research Council, Madrid, 28002, Spain.
National Centre for Genome Analysis, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, 08028, Spain.
Proc Natl Acad Sci U S A. 2019 May 14;116(20):10103-10112. doi: 10.1073/pnas.1816781116. Epub 2019 Apr 22.
Physical exercise has positive effects on cognition, but very little is known about the inheritance of these effects to sedentary offspring and the mechanisms involved. Here, we use a patrilineal design in mice to test the transmission of effects from the same father (before or after training) and from different fathers to compare sedentary- and runner-father progenies. Behavioral, stereological, and whole-genome sequence analyses reveal that paternal cognition improvement is inherited by the offspring, along with increased adult neurogenesis, greater mitochondrial citrate synthase activity, and modulation of the adult hippocampal gene expression profile. These results demonstrate the inheritance of exercise-induced cognition enhancement through the germline, pointing to paternal physical activity as a direct factor driving offspring's brain physiology and cognitive behavior.
体育锻炼对认知有积极影响,但对于这些影响如何遗传给久坐不动的后代以及涉及的机制知之甚少。在这里,我们使用雄性系设计在小鼠中测试来自同一父亲(训练前或训练后)和不同父亲的影响的传递,以比较久坐不动和跑步父亲的后代。行为学、立体学和全基因组序列分析表明,父代认知能力的提高通过生殖系遗传给后代,同时伴随着成年神经发生增加、线粒体柠檬酸合酶活性增强以及成年海马体基因表达谱的调节。这些结果表明,运动诱导的认知增强可以通过生殖系遗传,表明父体的体育活动是直接影响后代大脑生理学和认知行为的因素。