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[维生素A和E对视网膜溶酶体结构功能状态的影响]

[Effect of vitamins A and E on the structural-functional state of retinal lysosomes].

作者信息

Leus N F, Metelitsyna I P

出版信息

Ukr Biokhim Zh (1978). 1987 Jan-Feb;59(1):75-9.

PMID:3101255
Abstract

Vitamins A and E (alpha-tocopheryl-acetate and retinol-palmitate) are studied for their effect on structural and functional state of retina lysosomes. These vitamins are shown to exert a pronounced membrane-tropic effect on lysosomes. Vitamin E in chosen concentrations stabilizes membranes of retina lysosomes both in the in vitro and in vivo experiments. Vitamin A acts on them as a labilizing agent. The mentioned effect of vitamins may be corrected by low-energy radiation of the monochromatic coherent light (lambda = 632.8 nm). It is substantiated experimentally that the stabilizing effect of vitamin E may be intensified in case of the action combined with laser radiation on lysosomes. The labilizing effect of vitamin A on membranes of organelles under study may be weakened by application of laser radiation of low intensities.

摘要

研究了维生素A和E(α-生育酚乙酸酯和视黄醇棕榈酸酯)对视网膜溶酶体结构和功能状态的影响。结果表明,这些维生素对溶酶体具有显著的膜向性作用。在体外和体内实验中,特定浓度的维生素E均可稳定视网膜溶酶体的膜。维生素A则作为一种不稳定剂作用于溶酶体膜。上述维生素的作用可通过单色相干光(λ = 632.8 nm)的低能辐射得到纠正。实验证明,维生素E与激光辐射联合作用于溶酶体时,其稳定作用会增强。低强度激光辐射可减弱维生素A对所研究细胞器膜的不稳定作用。

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