Leus N F, Metelitsyna I P
Ukr Biokhim Zh (1978). 1987 Jan-Feb;59(1):75-9.
Vitamins A and E (alpha-tocopheryl-acetate and retinol-palmitate) are studied for their effect on structural and functional state of retina lysosomes. These vitamins are shown to exert a pronounced membrane-tropic effect on lysosomes. Vitamin E in chosen concentrations stabilizes membranes of retina lysosomes both in the in vitro and in vivo experiments. Vitamin A acts on them as a labilizing agent. The mentioned effect of vitamins may be corrected by low-energy radiation of the monochromatic coherent light (lambda = 632.8 nm). It is substantiated experimentally that the stabilizing effect of vitamin E may be intensified in case of the action combined with laser radiation on lysosomes. The labilizing effect of vitamin A on membranes of organelles under study may be weakened by application of laser radiation of low intensities.
研究了维生素A和E（α-生育酚乙酸酯和视黄醇棕榈酸酯）对视网膜溶酶体结构和功能状态的影响。结果表明，这些维生素对溶酶体具有显著的膜向性作用。在体外和体内实验中，特定浓度的维生素E均可稳定视网膜溶酶体的膜。维生素A则作为一种不稳定剂作用于溶酶体膜。上述维生素的作用可通过单色相干光（λ = 632.8 nm）的低能辐射得到纠正。实验证明，维生素E与激光辐射联合作用于溶酶体时，其稳定作用会增强。低强度激光辐射可减弱维生素A对所研究细胞器膜的不稳定作用。
