Yamazaki N, Nagaoka A, Nagawa Y
Yakubutsu Seishin Kodo. 1986 Sep;6(3):359-66.
The effects of a few drugs, which are known to activate central nervous system, on scopolamine-induced impairment of short-term memory (STM) were studied in a delayed alternation task in rats. Rats were initially trained using a delayed alternation task in which a forced run to one arm of a T-maze was followed by a free-choice run. A correct free-choice response was defined as a turn toward the arm opposite to that in the forced run, and was rewarded with food pellets. After repeated training of the 60 sec-delayed alternation task, the treatment with scopolamine (0.2 mg/kg, ip) at 20 min before the test resulted in a significant decrement in the correct response. The scopolamine-induced impairment of STM was significantly antagonized by DN-1417 (10 mg/kg, ip) given 1 hr before the test. However, TRH (3-30 mg/kg, ip) and methamphetamine (0.2-1.0 mg/kg, ip) did not improve the scopolamine-induced impairment in the task. In rats without treatment with scopolamine, these drugs did not affect the percent correct response. These results suggest that DN-1417 may have an improving effect on the impairment of STM induced by a decreased cholinergic activity.
在大鼠的延迟交替任务中，研究了几种已知可激活中枢神经系统的药物对东莨菪碱诱导的短期记忆（STM）损伤的影响。最初使用延迟交替任务训练大鼠，即在T型迷宫的一个臂上进行强制奔跑后进行自由选择奔跑。正确的自由选择反应定义为转向与强制奔跑相反的臂，并给予食物颗粒作为奖励。在对60秒延迟交替任务进行重复训练后，在测试前20分钟腹腔注射东莨菪碱（0.2mg/kg）导致正确反应显著减少。在测试前1小时腹腔注射DN-1417（10mg/kg）可显著拮抗东莨菪碱诱导的STM损伤。然而，促甲状腺激素释放激素（TRH，3-30mg/kg，腹腔注射）和甲基苯丙胺（0.2-1.0mg/kg，腹腔注射）并未改善东莨菪碱诱导的该任务损伤。在未用东莨菪碱处理的大鼠中，这些药物不影响正确反应百分比。这些结果表明，DN-1417可能对胆碱能活性降低诱导的STM损伤具有改善作用。
