Anokhina I D, Bol'shakova T D, Bremer G P, Buniatian A F, Ignatenko L L
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(11):1703-8.
The catecholamine and adrenocortical systems in 52 patients with depression were studied with regard to the degree of their emotional tension. On the basis of the clinical characteristics of the depressive syndrome the patients were divided into two groups: the stressory hyperergic type (Group 1) and the torpid hypoergic type (Group 2). Some characteristics of the studied systems proved common for both groups: they increased secretion of 11-hydroxycorticosteroids and impairment of the mechanisms of negative feedback in the regulation of adrenocortical activity, as well as a decrease in the excretion of dopamine, adrenaline, and DOPA in the presence of a relative acceleration of catecholamine inactivation. Along with the characteristics common for all the patients studied, the authors revealed a highly significant difference in noradrenaline excretion between Groups 1 and 2: it was normal in Group 1 and decreased three-fold in Group 2. The findings obtained are discussed in the light of the catecholamine hypothesis of depression development.
对52例抑郁症患者的儿茶酚胺和肾上腺皮质系统进行了研究，研究内容涉及他们的情绪紧张程度。根据抑郁综合征的临床特征，将患者分为两组：应激性高敏型（第1组）和迟钝性低敏型（第2组）。研究发现，这两个系统的一些特征在两组中是相同的：它们会增加11-羟基皮质类固醇的分泌，破坏肾上腺皮质活动调节中的负反馈机制，并且在儿茶酚胺失活相对加速的情况下，多巴胺、肾上腺素和多巴的排泄量会减少。除了所有研究患者共有的特征外，作者还发现第1组和第2组在去甲肾上腺素排泄方面存在高度显著差异：第1组正常，而第2组则减少了三倍。根据抑郁症发展的儿茶酚胺假说对所得结果进行了讨论。
