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[食物过敏的流行病学研究结果与局限性。聚焦热带国家]

[Results and limitations of epidemiological studies on food allergy. Focus on tropical countries].

作者信息

Sánchez Andrés, Sánchez Jorge, Cardona Ricardo

机构信息

Universidad de Antioquía, Grupo de Alergología Clínica y Experimental, Antioquía, Colombia.

出版信息

Rev Alerg Mex. 2019 Jan-Mar;66(1):9-17. doi: 10.29262/ram.v66i1.340.

Abstract

Allergy and food atopy are a consequence of immune responses unadapted to antigens mediated by common and otherwise harmless foods. Food allergy (AF) occurs frequently in children under three years of 3 to 15%, as well as in people over 6 to 8%. AF may be mediated by immunoglobulin E or cellular mechanisms and may present with a wide variety of symptoms in the skin, respiratory and gastrointestinal tracts. Due to its increasing frequency, adverse reactions to food have been the subject of extensive study, especially in North America and Europe, but few studies have been conducted in other areas such as South America, Africa and Asia. The variety of foods and preparation methods are part of the cultural identity of each population, so the main foods that cause symptoms vary between different regions, especially between populations located in the tropics and subtropical populations. This article reviews the available information on the epidemiology of food sensitization and food allergies in tropical regions and explores the different epidemiological data of that region, taking into account the main foods involved, the underlying immune mechanism and the associated symptoms. In addition, we identify possible limitations and questions that arise from studies conducted in tropical countries, which helps generate objectives for future research in the region.

摘要

过敏和食物特应性是免疫系统对常见且原本无害的食物介导的抗原产生不适应反应的结果。食物过敏(AF)在3岁以下儿童中频繁发生,发生率为3%至15%,在6岁以上人群中发生率为6%至8%。AF可能由免疫球蛋白E或细胞机制介导,并可能在皮肤、呼吸道和胃肠道出现多种症状。由于其发生率不断上升,食物不良反应已成为广泛研究的主题,尤其是在北美和欧洲,但在南美洲、非洲和亚洲等其他地区进行的研究较少。食物种类和制备方法是各人群文化特征的一部分,因此引起症状的主要食物在不同地区有所不同,特别是在热带地区人群和亚热带人群之间。本文综述了热带地区食物致敏和食物过敏的流行病学现有信息,并考虑到所涉及的主要食物、潜在免疫机制和相关症状,探讨了该地区不同的流行病学数据。此外,我们确定了热带国家研究中可能存在的局限性和问题,这有助于为该地区未来的研究制定目标。

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