选择性自噬：RNA 从穹顶而来，调节 p62/SQSTM1。

Selective Autophagy: RNA Comes from the Vault to Regulate p62/SQSTM1.

机构信息

Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø-The Arctic University of Norway, 9037 Tromsø, Norway.

出版信息

Curr Biol. 2019 Apr 22;29(8):R297-R299. doi: 10.1016/j.cub.2019.03.008.

DOI:10.1016/j.cub.2019.03.008

PMID:31014491

Abstract

A new study shows that the oligomerization of p62/Sequestosome-1 (SQSTM1) - a selective autophagy receptor and signaling adapter - is regulated directly by vault RNA. This riboregulation negatively affects the aggregation state of p62 and thereby its autophagic degradation and its role as a selective autophagy receptor.

摘要

一项新的研究表明，p62/Sequestosome-1（SQSTM1）——一种选择性自噬受体和信号适配器——的寡聚化直接受 vault RNA 的调控。这种核糖调控会对 p62 的聚集状态产生负面影响，从而影响其自噬降解及其作为选择性自噬受体的作用。