Oncology Unit, Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
Oncology Unit, Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece.
Crit Rev Oncol Hematol. 2019 May;137:9-17. doi: 10.1016/j.critrevonc.2019.02.009. Epub 2019 Feb 28.
Advanced-inoperable cervical cancer is a challenging entity due to increased percentage of locoregional and distant recurrences. Furthermore, recurrent cervical cancer not amenable to radical treatment as well as de novo metastatic disease are considered incurable with dismal prognosis. Well-designed clinical trials conducted during the last 30 years have revealed the active chemotherapeutic agents as well as their optimal combinations. The rational approach that has led to the current treatment algorithms as well as the introduction of targeted therapies based on the knowledge of the molecular pathogenesis of the disease are discussed in this review.
晚期无法手术的宫颈癌由于局部和远处复发的比例增加而成为一个极具挑战性的实体。此外，不能进行根治性治疗的复发性宫颈癌以及新出现的转移性疾病，由于预后不佳，被认为是无法治愈的。在过去 30 年中进行的精心设计的临床试验揭示了有效的化疗药物及其最佳组合。本文讨论了这一合理方法如何导致目前的治疗方案，以及基于疾病分子发病机制的知识引入靶向治疗。
