Cazajous T, Prevot F, Kerbiriou A, Milhes M, Grisez C, Tropee A, Godart C, Aragon A, Jacquiet P
Selarl vétérinaire du piémont, Zone commerciale espace Pyrénées, 64800, Mirepeix, France.
UMT Santé des Petits Ruminants, UMR INRA/ENVT, 1225 Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire, 23, chemin des Capelles, BP 87614, 31 076 Toulouse, Cedex 03, France.
Vet Parasitol Reg Stud Reports. 2018 Dec;14:103-105. doi: 10.1016/j.vprsr.2018.09.005. Epub 2018 Sep 14.
Anthelmintic resistance was explored by fecal egg count reduction test in a sheep flock from the French Pyrenees at the request of the veterinary practitioner after a poor response to anthelmintics was noted. The FECRT confirmed the suspicion with a mean percentage of reduction in egg excretions of 45% (CI 95%: - 40 to 78.5) and 0% (CI95%: - 162 to 49) within the ivermectin and the benzimidazole groups respectively. Haemonchus contortus was shown to be the IVM and BZ resistant species after morphological and molecular characterizations whereas Teladorsagia circumcincta was probably resistant to BZ only. The H. contortus population was still susceptible to moxidectin, closantel and levamisole. As this sheep flock is a transhumant flock, the spread of this multiple-resistant Haemonchus contortus population to the other sheep flocks sharing the same pastures in Pyrenean Mountains is highly likely. From the knowledge of the authors, this is the first report of multi-resistance to ivermectin and benzimidazole of a Haemonchus contortus population in mainland France.
应兽医从业者的要求，在观察到驱虫药效果不佳后，通过粪便虫卵计数减少试验对来自法国比利牛斯山脉的一群绵羊的抗驱虫药情况进行了研究。粪便虫卵计数减少试验证实了怀疑，伊维菌素组和苯并咪唑组的虫卵排泄减少平均百分比分别为45%（95%置信区间：-40至78.5）和0%（95%置信区间：-162至49）。经形态学和分子特征鉴定，捻转血矛线虫被证明对伊维菌素和苯并咪唑具有抗性，而环形泰勒虫可能仅对苯并咪唑具有抗性。捻转血矛线虫种群对莫西菌素、氯氰碘柳胺和左旋咪唑仍敏感。由于这群绵羊是游牧羊群，这种多重耐药的捻转血矛线虫种群极有可能传播到比利牛斯山脉共享相同牧场的其他羊群。据作者所知，这是法国大陆捻转血矛线虫种群对伊维菌素和苯并咪唑多重耐药的首次报告。
