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芬兰炎性风湿性疾病的发病率。

Incidence of inflammatory rheumatic diseases in Finland.

作者信息

Isomäki H, Raunio J, von Essen R, Hämeenkorpi R

出版信息

Scand J Rheumatol. 1978;7(3):188-92. doi: 10.3109/03009747809095652.

Abstract

The incidence of inflammatory joint diseases was estimated by using two patient series. Firstly, the total yearly incidence of all such diseases together was estimated in a population of 15 600 persons of 16 years of age or older. Secondly, this overall incidence was divided by the ratio of different diseases obtained from a larger series of patients. The incidence of all inflammatory joint diseases was 218/100 000/year, 182 in males and 250 in females. The incidence was highest in middle age and lowest in old age. The incidence of ill-defined arthritides was five times that of definite rheumatoid arthritis in the youngest age group but in the oldest their frequencies were equal. In the whole population, the proportion of ill-defined arthritides was 2/5, of definite RA 1/5, of HL-A B27 associated diseases 1/5, and of other diseases 1/5 of the total incidence of inflammatory joint diseases. Because the frequency of HL-A B27 in all patients surveyed was about 40%, only half of the patients with this antigen showed a clinical picture of ankylosing spondylitis, Reiter's disease, or reactive arthritis.

摘要

采用两个患者系列对炎性关节疾病的发病率进行了估算。首先,在15600名16岁及以上人群中估算所有此类疾病的年总发病率。其次,将这一总体发病率除以从更多患者系列中得出的不同疾病的比例。所有炎性关节疾病的发病率为218/10万/年,男性为182/10万/年,女性为250/10万/年。发病率在中年最高,老年最低。在最年轻的年龄组中,未明确诊断的关节炎发病率是明确类风湿关节炎的5倍,但在最年长的年龄组中,二者发病率相等。在整个人口中,未明确诊断的关节炎占炎性关节疾病总发病率的2/5,明确的类风湿关节炎占1/5,HL-A B27相关疾病占1/5,其他疾病占1/5。由于在所有接受调查的患者中HL-A B27的频率约为40%,因此只有一半携带该抗原的患者表现出强直性脊柱炎、赖特综合征或反应性关节炎的临床症状。

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