Kosaka A, Kuzuoka M, Yamafuji K, Imaizumi A, Hattori Y, Yamashita A
Gan To Kagaku Ryoho. 1987 Feb;14(2):516-22.
With the aim of clarifying the nature of the synergistic action of LNT with endocrine therapy for mammary tumor, the effect of LNT post-treatment was investigated in rats with DMBA-induced mammary tumors and also in patients with recurrent breast cancer. LNT injection following surgical therapy (Ax + Ox) resulted in a much greater regression of tumor growth than that obtained by surgery alone, but not after medical therapy (Tamoxifen). Image analysis using an immunohistochemical technique revealed that LNT-surgical therapy resulted in marked atrophy of tumors and as well as intense infiltration of T cells, B cells and macrophages into the stroma around the tumor. Blood prolactin level was greatly reduced by LNT injection. A clinical randomized controlled study demonstrated the efficacy and safety of LNT post-treatment with surgical therapy in 33 patients with recurrent breast cancer. The mode of the synergistic action of LNT in combination with endocrine therapy on hormone-dependent tumors was discussed.
为阐明香菇多糖（LNT）与内分泌疗法联合治疗乳腺肿瘤的协同作用本质，我们对二甲基苯蒽（DMBA）诱导的乳腺肿瘤大鼠以及复发性乳腺癌患者进行了LNT治疗后的效果研究。手术治疗（腋窝清扫术+卵巢切除术）后注射LNT，肿瘤生长的消退程度比单纯手术治疗显著增大，但在药物治疗（他莫昔芬）后则不然。采用免疫组化技术进行图像分析显示，LNT与手术治疗联合可导致肿瘤明显萎缩，同时肿瘤周围基质中有大量T细胞、B细胞和巨噬细胞浸润。注射LNT可使血液催乳素水平大幅降低。一项临床随机对照研究证实了LNT联合手术治疗对33例复发性乳腺癌患者进行治疗后的有效性和安全性。本文还讨论了LNT联合内分泌疗法对激素依赖性肿瘤的协同作用模式。
