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采用生物增强和受体微骨折制备技术的股骨内侧髁骨软骨异体移植术

Osteochondral Allograft Transplantation of the Medial Femoral Condyle With Orthobiologic Augmentation and Graft-Recipient Microfracture Preparation.

作者信息

Gwosdz James, Rosinski Alexander, Chakrabarti Moyukh, Woodall Brittany M, Elena Nicholas, McGahan Patrick J, Chen James L

机构信息

Advanced Orthopaedics and Sports Medicine, San Francisco, California, U.S.A.

出版信息

Arthrosc Tech. 2019 Feb 25;8(3):e321-e329. doi: 10.1016/j.eats.2018.11.008. eCollection 2019 Mar.

Abstract

Osteochondritis dissecans (OCD) has been recognized for over 100 years yet still poses treatment challenges owing to both the avascular nature of articular cartilage and the inability to generate hyaline cartilage. The knee is most commonly involved, and without repair, patients have chronic knee pain, loose bodies, and early-onset osteoarthritis. There are a number of surgical techniques for repairing OCD, some of which are still being refined. Currently, common procedures used to treat OCD lesions include microfracture, autologous chondrocyte implantation, osteochondral autograft transplantation, and osteochondral allograft transplantation. In this Technical Note, we describe osteochondral allograft transplantation with the addition of platelet-rich plasma and graft-recipient microfracture. We believe the micropores augment the osteoconductive and osteoinductive properties of the allograft and aid in the incorporation of the allograft plug by improving angiogenesis, enhancing clot formation in the allograft, and providing a homogeneous environment for remodeling.

摘要

剥脱性骨软骨炎(OCD)已被认识超过100年,但由于关节软骨的无血管性质以及无法生成透明软骨,仍然带来治疗挑战。膝关节最常受累,未经修复的患者会出现慢性膝关节疼痛、游离体和早发性骨关节炎。有多种用于修复OCD的手术技术,其中一些仍在不断完善。目前,用于治疗OCD病变的常见手术包括微骨折、自体软骨细胞植入、骨软骨自体移植和骨软骨异体移植。在本技术说明中,我们描述了添加富血小板血浆和受者微骨折的骨软骨异体移植。我们认为微孔增强了异体移植的骨传导性和骨诱导性,并通过改善血管生成、增强异体移植中的血凝块形成以及为重塑提供均匀环境来帮助异体移植栓的整合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f8/6475622/f76f71bd3f60/gr1.jpg

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