血清素对青蛙脊髓中受损和完整运动神经元的功能特性具有不同的调节作用。
Serotonin Modulates Differently the Functional Properties of Damaged and Intact Motoneurons in the Frog Spinal Cord.
作者信息
Kalinina N I, Zaitsev A V, Vesselkin N P
机构信息
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223, St. Petersburg, Russia.
Institute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia.
出版信息
Dokl Biol Sci. 2019 May;484(1):5-9. doi: 10.1134/S0012496619010046. Epub 2019 Apr 23.
When studying a preparation of the isolated spinal cord segment of an adult frog, damaged and intact lumbar motoneurons were found to differ significantly in the membrane potential, input resistance and the action potential properties (amplitude, duration, fast and medium phases of the afterhyperpolarization, and the frequency of spikes). Serotonin (5-HT) reduced the amplitude of afterpolarization and increased the frequency of the spikes of the intact neurons, while in the damaged motoneurons, 5-HT increased the amplitude of afterpolarization and had no effect on the frequency of discharges.
在研究成年青蛙离体脊髓节段的标本时，发现受损和未受损的腰段运动神经元在膜电位、输入电阻以及动作电位特性（幅度、持续时间、超极化后电位的快速和中间相以及峰频率）方面存在显著差异。5-羟色胺（5-HT）降低了未受损神经元超极化后电位的幅度并增加了其峰频率，而在受损的运动神经元中，5-HT增加了超极化后电位的幅度且对放电频率没有影响。
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