Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 4300030, China.
Curr Med Sci. 2019 Apr;39(2):190-195. doi: 10.1007/s11596-019-2018-2. Epub 2019 Apr 23.
Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality in obstetrics worldwide. No effective treatments to reduce its incidence and severity in clinical practice are currently available. A variety of hypotheses have been generated aiming to explain the origins of PE, notably being the genetic predispositions and placental dysfunction. As regard to placental dysfunction, much progress has been made in basic research and several potential therapeutic targets have been identified. This review will discuss in detail the potential therapeutic targets in PE models including uteroplacental blood flow, oxidative stress, vasoactive factors and inflammation/immune response, and introduce the evolving technologies for placental research nowadays.
子痫前期 (PE) 仍然是全球产科孕产妇和围产儿发病率和死亡率的主要原因。目前临床上尚无有效治疗方法来降低其发病率和严重程度。已经提出了多种假说，旨在解释 PE 的起源，特别是遗传易感性和胎盘功能障碍。至于胎盘功能障碍，基础研究取得了很大进展，已经确定了几个潜在的治疗靶点。这篇综述将详细讨论包括子宫胎盘血流、氧化应激、血管活性因子和炎症/免疫反应在内的 PE 模型中的潜在治疗靶点，并介绍当前胎盘研究的新兴技术。
