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[生物力学因素在青光眼评估中的应用研究综述]

[Review of studies on the application of biomechanical factors in the evaluation of glaucoma].

作者信息

Song Hongfang, Li Qi, Wang Ningli, Wang Wenjia, Long Xiaoxue, Liu Zhicheng

机构信息

Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Beijing 100069, P.R.China;School of Biomedical Engineering, Capital Medical University, Beijing 100069, P.R.China.

Beijing Tongren Hospital, Capital Medical University, Beijing 100005, P.R.China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2019 Apr 25;36(2):315-319. doi: 10.7507/1001-5515.201809058.

DOI:10.7507/1001-5515.201809058
PMID:31016950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9929904/
Abstract

There are so many biomechanical risk factors related with glaucoma and their relationship is much complex. This paper reviewed the state-of-the-art research works on glaucoma related mechanical effects. With regards to the development perspectives of studies on glaucoma biomechanics, a completely novel biomechanical evaluation factor -- Fractional Flow Reserve (FPR) for glaucoma was proposed, and developing clinical application oriented glaucoma risk assessment algorithm and application system by using the new techniques such as artificial intelligence and machine learning were suggested.

摘要

与青光眼相关的生物力学风险因素众多,且它们之间的关系极为复杂。本文综述了青光眼相关力学效应的最新研究成果。关于青光眼生物力学研究的发展前景,提出了一种全新的青光眼生物力学评估因子——分数血流储备(FPR),并建议利用人工智能和机器学习等新技术开发面向临床应用的青光眼风险评估算法及应用系统。

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本文引用的文献

1
The intraocular pressure could not be used to determine the intracranial pressure in patients with hydrocephalus.眼压不能用于确定脑积水患者的颅内压。
Int J Neurosci. 2019 Jan;129(1):42-48. doi: 10.1080/00207454.2018.1486832. Epub 2018 Nov 5.
2
Measurement and Associations of the Optic Nerve Subarachnoid Space in Normal Tension and Primary Open-Angle Glaucoma.正常眼压性青光眼和原发性开角型青光眼视神经蛛网膜下腔的测量及相关性。
Am J Ophthalmol. 2018 Feb;186:128-137. doi: 10.1016/j.ajo.2017.11.024. Epub 2017 Dec 12.
3
In-vivo effects of intraocular and intracranial pressures on the lamina cribrosa microstructure.眼内压和颅内压对筛板微观结构的体内效应。
PLoS One. 2017 Nov 21;12(11):e0188302. doi: 10.1371/journal.pone.0188302. eCollection 2017.
4
Glaucoma in patients with shunt-treated normal pressure hydrocephalus.分流治疗正常压力脑积水患者的青光眼。
J Neurosurg. 2018 Oct;129(4):1078-1084. doi: 10.3171/2017.5.JNS163062. Epub 2017 Nov 17.
5
Normal-Tension Glaucoma Has Normal Intracranial Pressure: A Prospective Study of Intracranial Pressure and Intraocular Pressure in Different Body Positions.正常眼压性青光眼的颅内压正常:不同体位下颅内压和眼内压的前瞻性研究。
Ophthalmology. 2018 Mar;125(3):361-368. doi: 10.1016/j.ophtha.2017.09.022. Epub 2017 Oct 31.
6
Predicting Vision-Related Disability in Glaucoma.预测青光眼相关的视力障碍。
Ophthalmology. 2018 Jan;125(1):22-30. doi: 10.1016/j.ophtha.2017.08.034. Epub 2017 Oct 13.
7
The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular, Biomechanical, and Biochemical Aspects of the Disease.青光眼的糖质新生假说:整合疾病血管、生物力学和生化方面的统一概念。
Biomed Res Int. 2017;2017:5123148. doi: 10.1155/2017/5123148. Epub 2017 Aug 29.
8
Lamina cribrosa in glaucoma.青光眼视盘筛板。
Curr Opin Ophthalmol. 2017 Mar;28(2):113-119. doi: 10.1097/ICU.0000000000000354.
9
Dynamic changes of the intraocular pressure and the pressure of cerebrospinal fluid in nonglaucomatous neurological patients.非青光眼性神经疾病患者眼压和脑脊液压力的动态变化
Acta Ophthalmol. 2017 Mar;95(2):e138-e143. doi: 10.1111/aos.13236. Epub 2016 Oct 24.
10
Finite Element Modeling of Factors Influencing Optic Nerve Head Deformation Due to Intracranial Pressure.颅内压影响视神经乳头变形因素的有限元建模
Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1901-11. doi: 10.1167/iovs.15-17573.