a Department of Cardiology, Copenhagen University Hospital , Copenhagen , Denmark.
b Department of Anesthesia and Intensive Care, Helsingborg Hospital , Helsingborg , Sweden.
Biomarkers. 2019 Sep;24(6):584-591. doi: 10.1080/1354750X.2019.1609580. Epub 2019 May 31.
Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 h after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 h after OHCA. The primary endpoint was neurological outcome. Median (quartile 1 - quartile 3) tau-A (ng/ml) values were 58 (43-71) versus 51 (43-67), 72 (57-84) versus 71 (59-82) and 76 (61-92) versus 75 (64-89) for good versus unfavourable outcome at 24, 48 and 72 h, respectively ( = 0.95). Median tau C (ng/ml) values were 38 (29-50) versus 36 (29-49), 49 (38-58) versus 48 (33-59) and 48 (39-59) versus 48 (36-62) ( = 0.95). Tau-A and tau-C did not predict neurological outcome (area under the receiver-operating curve at 48 h; tau-A: 0.51 and tau-C: 0.51). Serum levels of tau fragments were unable to predict neurological outcome after OHCA.
缺氧性脑损伤是心肺复苏后院外心脏骤停（OHCA）患者死亡的主要原因，预后预测具有挑战性。本研究旨在评估两种tau 片段作为神经预后血清生物标志物的潜力。 这项单中心亚研究纳入了 171 例随机分配至 33°C 目标温度管理（TTM）或 36°C TTM 组的患者，OHCA 后 24 小时内进行 24、48 和 72 小时的血清 tau 片段（tau-A 和 tau-C）测量。OHCA 后 24、48 和 72 小时，tau-A（ng/ml）中位数（四分位数 1-四分位数 3）分别为 58（43-71）比 51（43-67），72（57-84）比 71（59-82）和 76（61-92）比 75（64-89），良好与不良结局相比（ = 0.95）。tau-C（ng/ml）中位数分别为 38（29-50）比 36（29-49），49（38-58）比 48（33-59）和 48（39-59）比 48（36-62）（ = 0.95）。tau-A 和 tau-C 均不能预测神经结局（48 小时时的接收者操作特征曲线下面积；tau-A：0.51，tau-C：0.51）。 OHCA 后，tau 片段的血清水平无法预测神经结局。
