Merkur'eva R V, Dolinskaia S I, Shekhtman A B, Gasanov T G, Gadzhieva T I
Biull Eksp Biol Med. 1987 Feb;103(2):198-200.
The results of a comparative biochemical and electron-microscopic study of membrane-injuring effect of N-nitrosodimethylamine--a chemical carcinogen widespread in the environment are reviewed. It has been established that in vivo and in vitro membrane-injuring effect of nitrosodimethylamine is characterized by reduced activity of membrane-bound enzymes of endoplasmic reticulum (UDP-glucuronyltransferase and glucose-6-phosphatase) accompanied by alterations in functional morphology of cells and intracellular structure.
本文综述了对N-亚硝基二甲胺（一种广泛存在于环境中的化学致癌物）膜损伤作用的比较生化和电子显微镜研究结果。已证实，亚硝基二甲胺在体内和体外的膜损伤作用表现为内质网的膜结合酶（UDP-葡萄糖醛酸基转移酶和葡萄糖-6-磷酸酶）活性降低，同时伴有细胞功能形态和细胞内结构的改变。
