[去甲丙咪嗪急性或慢性给药对自由活动大鼠脑蛋白中蛋氨酸掺入局部水平的影响]
[Effects of acute or chronic administration of desmethylimipramine on the local level of methionine incorporation in cerebral proteins in freely moving rats].
作者信息
Rossatto C, Lestage P, Dalery J, Bobillier P
出版信息
C R Acad Sci III. 1986;303(20):761-4.
PMID:3101989
Abstract
Incorporation of methionine into brain proteins has been measured by quantitative autoradiography after desmethylimipramine administration in rats. Acute treatment decreased protein synthesis in three regions: hippocampus, hypothalamus and habenula. After chronic treatment the decrease extended to four other regions: substantia nigra, raphe dorsalis, trigeminal nerve and hypophysis. An opposite effect was observed in the retrosplenial cortex.
摘要
在给大鼠施用去甲丙咪嗪后，已通过定量放射自显影法测定蛋氨酸掺入脑蛋白的情况。急性处理降低了三个区域的蛋白质合成：海马体、下丘脑和缰核。慢性处理后，降低范围扩展到其他四个区域：黑质、背侧中缝核、三叉神经和垂体。在压后皮质观察到相反的效果。
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