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用去甲丙咪嗪进行长期治疗可增加正常和松果体切除雄性大鼠下丘脑和神经垂体中的催产素含量。

Chronic treatment with desmethylimipramine increases the oxytocin content in the hypothalamus and neurohypophysis of normal and pinealectomized male rats.

作者信息

Juszczak M

机构信息

Department of Pathophysiology, School of Medicine, Lódź.

出版信息

Acta Physiol Pol. 1988 Jul-Aug;39(4):261-8.

PMID:3252689
Abstract

The effect of chronic treatment with desmethylimipramine (i.p., 10 mg/kg; twice daily over 5 days) on the content of oxytocin in the hypothalamus and neurohypophysis of normal and pinealectomized male rats has been investigated. Pinealectomy resulted in a decrease of oxytocin content in the hypothalamus and neurohypophysis. Treatment with desmethylimipramine (desipramine; DMI) was followed by a distinct increase of the oxytocin potency in the hypothalamus and neurohypophysis in both normal and pinealectomized rats. It may be supposed that chronic treatment with DMI inhibits the oxytocin release from neurohypophysis.

摘要

研究了用去甲丙咪嗪（腹腔注射，10毫克/千克；5天内每日两次）长期治疗对正常和松果体切除的雄性大鼠下丘脑和神经垂体中催产素含量的影响。松果体切除导致下丘脑和神经垂体中催产素含量降低。用去甲丙咪嗪（地昔帕明；DMI）治疗后，正常和松果体切除的大鼠下丘脑和神经垂体中的催产素效力均明显增加。可以推测，DMI长期治疗会抑制神经垂体释放催产素。

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