Kolesnikova L R, Darenskaya M A, Kolesnikova L I, Grebenkina L A, Korytov L I, Batoroev Yu K, Belinskaya E I, Mikhalevich I M, Kolesnikov S I
Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Irkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia.
Bull Exp Biol Med. 2019 Apr;166(6):722-725. doi: 10.1007/s10517-019-04426-y. Epub 2019 Apr 24.
It was shown that the intensity of morphological changes in the dental system tissues (periodontium and pulp) of ISIAH rats depends on the mode of stress exposure. Acute stress was associated with a significant increase in the area of periodontal and pulp vessels, a decrease in the area of connective tissue of these components, and an increase in the thickness of the vascular endothelium. Chronic stress in these animals induced an increase in the thickness of the endothelial layer of the periodontal and pulp vessels, fibromatosis (increase in the number of fibroblasts), and a sharp decrease in the level of odontoblasts.
结果表明，ISIAH大鼠牙齿系统组织（牙周组织和牙髓）形态学变化的强度取决于应激暴露方式。急性应激与牙周和牙髓血管面积显著增加、这些组织结缔组织面积减少以及血管内皮厚度增加有关。这些动物的慢性应激导致牙周和牙髓血管内皮层厚度增加、纤维瘤病（成纤维细胞数量增加）以及成牙本质细胞水平急剧下降。
