Department of Chemistry, Virginia Commonwealth University, 1001 W Main St, Richmond, 23284, VA, USA.
Massey Cancer Center, Virginia Commonwealth University, 401 College St, Richmond, 23219, Virginia, USA.
Chem Commun (Camb). 2019 May 9;55(39):5607-5610. doi: 10.1039/c9cc02050k.
Highly cytotoxic agents have found an important niche in targeted anticancer therapy. Here we develop a new light release strategy for the targeting of one of these agents, 2-pyrrolinodoxorubicin, showing dramatic enhancements in toxicity with light and single digit nM potency.
高细胞毒性药物在靶向抗癌治疗中找到了重要的位置。在这里，我们为其中一种药物，即 2-吡咯啉阿霉素，开发了一种新的光释放策略，显示出光和单个位数 nM 效力的显著毒性增强。
