Dunne W M, Chusid M J
Diagn Microbiol Infect Dis. 1987 Feb;6(2):165-70. doi: 10.1016/0732-8893(87)90102-7.
Disk diffusion antibiograms were determined for mixtures of Pseudomonas aeruginosa morphotypes isolated from the sputum of patients with cystic fibrosis (CF). The results were compared with the predicted susceptibility patterns derived from the antibiograms of individual morphotypes within the mixture. Fifty separate cultures, each yielding two, three, or four distinct morphotypes of Pseudomonas aeruginosa were evaluated. Overall, the correlation between observed and predicted results was 92.2% with only 2.9% of all observations leading to major disagreements in susceptibility. These data suggest that mixed morphotype susceptibility is potentially a useful method to monitor the collective resistance of colonizing strains of Pseudomonas aeruginosa from the respiratory tract of patients with CF.
对从囊性纤维化（CF）患者痰液中分离出的铜绿假单胞菌形态型混合物进行了纸片扩散法药敏试验。将结果与混合物中各个形态型的药敏试验预测的敏感性模式进行比较。评估了50个单独的培养物，每个培养物产生两种、三种或四种不同的铜绿假单胞菌形态型。总体而言，观察结果与预测结果之间的相关性为92.2%，所有观察结果中只有2.9%导致药敏性出现重大分歧。这些数据表明，混合形态型药敏性可能是一种监测CF患者呼吸道中定植的铜绿假单胞菌菌株集体耐药性的有用方法。
