Gueldry S, Rochette L, Bralet J
Epilepsia. 1987 Mar-Apr;28(2):160-8. doi: 10.1111/j.1528-1157.1987.tb03642.x.
The acute effects of valproate (200 and 400 mg/kg), ethosuximide (200 and 400 mg/kg), phenytoin (25 and 50 mg/kg), and pentobarbital (30 and 60 mg/kg) on cerebral energy metabolism of rats were studied by measuring the cerebral content of energy metabolites and by evaluating the rate of metabolite utilization following decapitation. The treatments did not affect the levels of phosphocreatine (PCr), ATP, ADP, and AMP, but did enhance the glycogen or glucose stores. Pentobarbital induced a decrease in lactate, whereas valproate led to a decrease in pyruvate and an increase in lactate. Calculation of the metabolite fluxes after decapitation showed that all treatments delayed the rate of ATP utilization. The response was dose-dependent except with valproate. In addition, pentobarbital led to reductions in glucose utilization and lactate production, but the other drugs had no significant effect on glycolysis rate. The sparing effect on ATP utilization may be related to a membrane-stabilizing effect and may provide brain protection in case of excessive neuronal activation.
通过测量能量代谢物的脑内含量以及评估断头后代谢物的利用速率，研究了丙戊酸盐（200和400毫克/千克）、乙琥胺（200和400毫克/千克）、苯妥英（25和50毫克/千克）和戊巴比妥（30和60毫克/千克）对大鼠脑能量代谢的急性影响。这些处理未影响磷酸肌酸（PCr）、三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和一磷酸腺苷（AMP）的水平，但确实增加了糖原或葡萄糖储备。戊巴比妥使乳酸水平降低，而丙戊酸盐导致丙酮酸水平降低和乳酸水平升高。断头后代谢物流通量的计算表明，所有处理均延缓了ATP的利用速率。除丙戊酸盐外，该反应呈剂量依赖性。此外，戊巴比妥导致葡萄糖利用和乳酸生成减少，但其他药物对糖酵解速率无显著影响。对ATP利用的节约效应可能与膜稳定作用有关，并且在神经元过度激活的情况下可能提供脑保护。
