Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan; Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
Int J Pharm. 2019 Jun 30;565:41-49. doi: 10.1016/j.ijpharm.2019.04.059. Epub 2019 May 6.
The aim of the present study was to assess the potential of biocompatible polymeric nanosheets as topical and transdermal drug-delivery devices. Nanosheets are two-dimensional nanostructures with a thickness in the nanometer order, and their extremely large aspect ratios result in unique properties, including high transparency, flexibility, and adhesiveness. Nanosheet formulations containing betamethasone valerate (BV) as a model drug and consisting of poly (L-lactic acid) or poly (lactic-co-glycolic) acid were fabricated through a spin-coating-assisted layer-by-layer method using a water-soluble sacrificial membrane. The fabricated formulations could incorporate and release higher amounts of BV compared with a commercial ointment, and the amounts could be controlled by the polymers used, the amount of BV added, and the use of controlled-release membranes. The presence of BV had a minimal effect on thickness, transparency, adhesiveness, and moisture permeability of nanosheets, permitting their application to any area of skin for a long period of time. Therefore, this biocompatible polymeric nanosheet formulation represents a novel and promising topical and transdermal drug delivery device, which has potential to deliver drugs regardless of the area of skin.
本研究旨在评估生物相容性聚合物纳米片作为局部和透皮药物传递装置的潜力。纳米片是厚度在纳米量级的二维纳米结构，其极高的纵横比赋予了其独特的性质，包括高透明度、柔韧性和粘附性。载有倍他米松戊酸酯（BV）作为模型药物的纳米片制剂由聚（L-乳酸）或聚（乳酸-共-羟基乙酸）组成，通过使用水溶性牺牲膜的旋涂辅助层层法制备而成。与商业软膏相比，所制备的制剂可以包含和释放更多量的 BV，并且可以通过使用的聚合物、添加的 BV 量和使用控释膜来控制释放量。BV 的存在对纳米片的厚度、透明度、粘附性和水分渗透性的影响很小，允许它们在皮肤的任何部位长时间应用。因此，这种生物相容性聚合物纳米片制剂代表了一种新型的、有前途的局部和透皮药物传递装置，有潜力将药物递送到皮肤的任何部位。
