Panasiuk E N, Skliarov A Ia
Fiziol Zh SSSR Im I M Sechenova. 1986 Nov;72(11):1545-51.
The effect of prostaglandin E2 (PgE2) injected with histamine in dogs with stomach fistula, involved a decrease of volume of secreted gastric juice, production of hydrochloric acid and pepsin lessening as compared with the findings obtained in the effect of histamine alone. The inhibition of gastric secretion increases in combined injection of PgE2 with histamine and acetylcholine. After intramuscular injection of PgE2 the content of sodium ions in the blood serum of rats decreases, the concentration of potassium becoming higher. In the mucose membrane of stomach the content of sodium and potassium increases; oxygen pressure in the mucous membrane of stomach decreases after the injection of PgE2.
在有胃瘘的狗身上，前列腺素E2（PgE2）与组胺一起注射的效果，与单独使用组胺时相比，涉及分泌的胃液量减少、盐酸产生减少和胃蛋白酶生成减少。PgE2与组胺和乙酰胆碱联合注射时，对胃液分泌的抑制作用增强。大鼠肌肉注射PgE2后，血清中钠离子含量降低，钾离子浓度升高。胃黏膜中钠和钾的含量增加；注射PgE2后胃黏膜中的氧分压降低。
