Lai Y J, Hsu C Y
Bratisl Lek Listy. 2019;120(4):316-319. doi: 10.4149/BLL_2019_043.
This study investigated the association between serum uric acid (sUA) and stroke risk in men with hypertriglyceridemia.
Between 2002 and 2012, male patients with pure hypertriglyceridemia and a triglyceride (TG) level ≥ 150 mg/dL were enrolled. Eligible patients were categorized into two groups according to their sUA levels (≥ and < 8 mg/dL). Clinical characteristics and comorbidities that are risk factors for stroke were recorded and compared between the groups.
A total of 265 male patients (95 with sUA ≥ 8 mg/dL and 170 with sUA < 8 mg/dL) were enrolled. The incidence of ischemic type of stroke was significantly higher in patients with sUA ≥ 8 mg/dL (p = 0.038), particularly in the age range of 45-65 years. Multivariate Cox proportional analyses confirmed that age (p = 0.003) and UA (p = 0.019) were major predictive factors for stroke free (ischemic type of stroke) survival.
Among men with hypertriglyceridemia, the incidence rate of ischemic type of stroke significantly increased with sUA levels ≥ 8 mg/dL, particularly in men aged 45 to 65 years. Hyperuricemia is considered a potential predictive factor for ischemic type of stroke and may indicate the need for preventive management in patients with hypertriglyceridemia (Tab. 3, Fig. 1, Ref. 28).
本研究调查了高甘油三酯血症男性患者血清尿酸（sUA）与中风风险之间的关联。
在2002年至2012年期间，纳入了单纯高甘油三酯血症且甘油三酯（TG）水平≥150mg/dL的男性患者。符合条件的患者根据其sUA水平（≥8mg/dL和<8mg/dL）分为两组。记录并比较两组之间作为中风危险因素的临床特征和合并症。
共纳入265例男性患者（95例sUA≥8mg/dL，170例sUA<8mg/dL）。sUA≥8mg/dL的患者缺血性中风的发生率显著更高（p=0.038），特别是在45-65岁年龄范围内。多变量Cox比例分析证实，年龄（p=0.003）和尿酸（p=0.019）是无中风（缺血性中风类型）生存的主要预测因素。
在高甘油三酯血症男性中，sUA水平≥8mg/dL时缺血性中风的发生率显著增加，特别是在45至65岁的男性中。高尿酸血症被认为是缺血性中风类型的潜在预测因素，可能表明高甘油三酯血症患者需要进行预防性管理（表3，图1，参考文献28）。
