Boccardi Mariangela, Boccardi Virginia
Department of Psychiatry, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Section of Gerontology and Geriatrics, Santa Maria della Misericordia Hospital, 60132 Perugia, Italy.
Geriatrics (Basel). 2019 Feb 23;4(1):25. doi: 10.3390/geriatrics4010025.
Stress and depression are known to modulate the aging process, and might also affect telomere biology. In fact, exposure to some biochemical pathways involved in stress-related depression may contribute to an ''accelerated aging" phenotype, as well as the incidence of age-related diseases, including metabolic disorders and dementia. Basic studies support the notion that the telomere and telomerase system plays a pivotal role in the aging process and disease promotion. Interestingly, short and dysfunctional telomeres are associated with reduced lifespan, as shown in animal models. In this context, telomeres are very sensitive to stress, mindset, and lifestyle, and their rescue may be sufficient to restore cell and organism viability. This mini-review discusses conceptual models of healthy and active aging and their relationship with telomere biology and mental health.
已知压力和抑郁会调节衰老过程，也可能影响端粒生物学。事实上，暴露于与压力相关的抑郁所涉及的一些生化途径可能会导致“加速衰老”表型以及与年龄相关疾病的发生，包括代谢紊乱和痴呆症。基础研究支持这样一种观点，即端粒和端粒酶系统在衰老过程和疾病发展中起关键作用。有趣的是，如动物模型所示，短的和功能失调的端粒与寿命缩短有关。在这种情况下，端粒对压力、心态和生活方式非常敏感，挽救端粒可能足以恢复细胞和机体的活力。这篇小型综述讨论了健康和积极衰老的概念模型及其与端粒生物学和心理健康的关系。
