Kulacoglu Hakan, Köckerling Ferdinand
Ankara Hernia Center, Ankara, Turkey.
Department of Surgery, Centre for Minimally Invasive Surgery, Vivantes Klinikum, Berlin, Germany.
Front Surg. 2019 Apr 5;6:19. doi: 10.3389/fsurg.2019.00019. eCollection 2019.
This review aimed to present common points, intersections, and potential interactions or mutual effects for hernia and cancer. Besides direct relationships, indirect connections, and possible involvements were searched. A literature search of PubMed database was performed in July 2018 as well as a search of relevant journals and reference lists. The total number of screened articles was 1,422. Some articles were found in multiple different searches. A last PubMed search was performed during manuscript writing in December 2018 to update the knowledge. Eventually 427 articles with full text were evaluated, and 264 included, in this review. There is no real evidence for a possible common etiology for abdominal wall hernias and any cancer type. The two different diseases had been found to have some common points in the studies on genes, integrins, and biomarkers, however, to date no meaningful relationship has been identified between these points. There is also some, albeit rather conflicting, evidence for inguinal hernia being a possible risk factor for testicular cancer. Neoadjuvant or adjuvant therapeutic modalities like chemotherapy and radiotherapy may cause postoperative herniation with their adverse effects on tissue repair. Certain specific substances like bevacizumab may cause more serious complications and interfere with hernia repair. There are only two articles in PubMed directly related to the topic of "hernia and cancer." In one of these the authors claimed that there was no association between cancer development and hernia repair with mesh. The other article reported two cases of squamous-cell carcinoma developed secondary to longstanding mesh infections. As expected, the relationship between abdominal wall hernias and cancer is weak. Hernia repair with mesh does not cause cancer, there is only one case report on cancer development following a longstanding prosthetic material infections. However, there are some intersection points between these two disease groups which are worthy of research in the future.
本综述旨在阐述疝与癌症的共同点、交叉点以及潜在的相互作用或相互影响。除了直接关系外，还对间接联系和可能的关联进行了探究。2018年7月对PubMed数据库进行了文献检索，并检索了相关期刊和参考文献列表。筛选出的文章总数为1422篇。在多个不同检索中发现了一些重复的文章。在2018年12月撰写手稿期间进行了最后一次PubMed检索，以更新知识。最终，本综述评估了427篇全文文章，其中264篇被纳入。目前尚无确凿证据表明腹壁疝与任何癌症类型存在共同病因。然而，在关于基因、整合素和生物标志物的研究中发现这两种不同疾病有一些共同点，但迄今为止，这些共同点之间尚未发现有意义的关系。也有一些证据（尽管相当矛盾）表明腹股沟疝可能是睾丸癌的一个危险因素。新辅助或辅助治疗方式如化疗和放疗可能因其对组织修复的不良影响而导致术后疝形成。某些特定物质如贝伐单抗可能会引起更严重的并发症并干扰疝修补。PubMed中直接与“疝与癌症”主题相关的文章仅有两篇。其中一篇文章的作者声称癌症发展与使用补片进行疝修补之间没有关联。另一篇文章报道了两例因长期补片感染继发鳞状细胞癌的病例。正如预期的那样，腹壁疝与癌症之间的关系很弱。使用补片进行疝修补不会导致癌症，仅有一例关于长期假体材料感染后发生癌症的病例报告。然而，这两个疾病组之间存在一些交叉点，值得未来进行研究。
