McElroy S L, Keck P E, Pope H G
J Clin Psychopharmacol. 1987 Feb;7(1):16-24.
Sodium valproate has been reported to be effective in the treatment of recurrent major affective and schizoaffective disorders. The records of 36 consecutive patients with various psychiatric diagnoses, who received valproate at our center, were retrospectively reviewed. None of these patients displayed a diagnosable neurologic disorder or paroxysmal EEG activity. Sixteen (44%) of the 36 patients experienced a moderate to marked response to valproate. The diagnoses of bipolar or schizoaffective disorder and the presence of nonparoxysmal EEG abnormalities both predicted a favorable response. The authors conclude that valproate deserves further study as a possible treatment for major affective disorder.
据报道，丙戊酸钠在治疗复发性重性情感障碍和分裂情感性障碍方面有效。对在我们中心接受丙戊酸钠治疗的36例患有各种精神疾病诊断的连续患者的记录进行了回顾性研究。这些患者均未表现出可诊断的神经系统疾病或阵发性脑电图活动。36例患者中有16例（44%）对丙戊酸钠有中度至明显反应。双相情感障碍或分裂情感性障碍的诊断以及非阵发性脑电图异常的存在均预示着良好的反应。作者得出结论，丙戊酸钠作为重性情感障碍的一种可能治疗方法值得进一步研究。
