Micevych P E, Park S S, Akesson T R, Elde R
J Comp Neurol. 1987 Jan 1;255(1):124-36. doi: 10.1002/cne.902550110.
The hypothalamic distribution of cholecystokinin-immunoreactive (CCKI) cell bodies in colchicine-treated male and female rats was studied. Immunoreactive neurons were visualized along the anterior two-thirds of the third ventricle but were especially numerous in the preoptic periventricular nucleus. Dense aggregations of CCKI cells were found in the anterior magnocellular, posterior magnocellular, medial parvicellular, and posterior parvicellular divisions of the paraventricular nucleus. Both the supraoptic nucleus and the central, cell-dense part of the dorsomedial nucleus contained large numbers of CCKI cells. CCKI cells in the preoptic periventricular nucleus were more numerous in the female, as was a population of labeled cells in the dorsal medial preoptic area. However, CCKI cell bodies in this part of the medial preoptic area were larger in males than in females. Males had more CCKI cells in the central part of the medial preoptic nucleus and in the posterior magnocellular subdivision of the paraventricular nucleus. Both males and females had similar numbers of immunoreactive cells in the anterior magnocellular and the parvicellular divisions of the paraventricular nucleus as well as in the anterior hypothalamus, dorsal areas, dorsomedial nucleus, and supramammillary region. These data provide morphological evidence for a sexually differentiated hypothalamic CCKI system.
研究了秋水仙碱处理的雄性和雌性大鼠中胆囊收缩素免疫反应性（CCKI）细胞体在下丘脑的分布。免疫反应性神经元沿第三脑室前三分之二可见，但在视前室周核中尤其众多。在室旁核的前大细胞、后大细胞、内侧小细胞和后小细胞区发现了CCKI细胞的密集聚集。视上核和背内侧核的中央细胞密集部分都含有大量CCKI细胞。视前室周核中的CCKI细胞在雌性中更多，视前内侧背区的一群标记细胞也是如此。然而，视前内侧区这部分的CCKI细胞体在雄性中比在雌性中更大。雄性在视前内侧核中央部分和室旁核后大细胞亚区有更多的CCKI细胞。雄性和雌性在室旁核的前大细胞和小细胞区以及下丘脑前部、背侧区、背内侧核和乳头体上区的免疫反应性细胞数量相似。这些数据为下丘脑CCKI系统的性别分化提供了形态学证据。
