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抗生素骨水泥间隔物原位保留7年用于两阶段初次全膝关节置换术:一例报告

Antibiotic-impregnated articulating cement spacer maintained for 7 years in situ for two-stage primary total knee arthroplasty: a case report.

作者信息

Park Yong-Beom, Ha Chul-Won, Jang Jae Won, Kim Manyoung

机构信息

Department of Orthopedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul, 06973, South Korea.

Department of Orthopaedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

出版信息

BMC Musculoskelet Disord. 2019 Apr 25;20(1):179. doi: 10.1186/s12891-019-2571-7.

Abstract

BACKGROUND

Antibiotic-impregnated articulating cement spacers can maintain interim joint motion with the potential to enhance functional status and improve patient satisfaction. Articular surfaces with cement against cement have raised concerns regarding mechanical complications and cement debris during knee motion. However, long-term clinical conditions regarding these concerns are not well addressed.

CASE PRESENTATION

We report a case in which articulating cement spacers were maintained in situ for 7 years. The patient had severe left knee pain with an ankylosing knee and severe tricompartmental arthritis due to tuberculous infection. We planned to perform one- or two-stage primary total knee arthroplasty (TKA), depending on the presence of infection. Persistent osteomyelitis was found intraoperatively. The second-stage TKA was delayed on the patient's request. As the patient was satisfied with the improved knee function and pain relief after using articulating cement spacers. No symptom or sign that suggested recurrent infection or systemic toxicity was found during the 7-year follow-up. However, it seemed that the bone loss progressed insidiously. At the 7-year follow-up, a broken articulating cement spacer and medial femoral condylar fracture were found. The second-stage TKA was performed, and a considerable amount of bone loss surrounded by dense granulation tissue was observed intraoperatively. Excisional biopsy of the tissue revealed chronic foreign body reaction with infiltration of giant cells and macrophages.

CONCLUSION

Although the articular spacers were maintained for 7 years without major complications, regular observation of the development and progress of bone loss was required. Surgeons should take considerable bone loss into account during conversion TKA in patients with a prolonged retention of articulating cement spacers.

摘要

背景

抗生素浸渍的可活动骨水泥间隔物可维持关节的临时活动,有可能改善功能状态并提高患者满意度。骨水泥与骨水泥的关节面引发了人们对膝关节活动期间机械并发症和骨水泥碎屑的担忧。然而,关于这些担忧的长期临床情况尚未得到充分解决。

病例报告

我们报告了一例可活动骨水泥间隔物原位保留7年的病例。该患者因结核感染导致左膝严重疼痛、膝关节强直和严重的三关节腔关节炎。我们计划根据感染情况进行一期或二期初次全膝关节置换术(TKA)。术中发现持续性骨髓炎。根据患者要求,二期TKA手术推迟。由于患者对使用可活动骨水泥间隔物后膝关节功能改善和疼痛缓解感到满意。在7年的随访期间,未发现提示反复感染或全身毒性的症状或体征。然而,骨丢失似乎在不知不觉中进展。在7年随访时,发现一个可活动骨水泥间隔物断裂和股骨内侧髁骨折。进行了二期TKA手术,术中观察到大量骨丢失被致密的肉芽组织包围。对该组织进行切除活检显示为慢性异物反应,伴有巨细胞和巨噬细胞浸润。

结论

尽管关节间隔物保留了7年且无重大并发症,但仍需要定期观察骨丢失的发展和进展情况。对于可活动骨水泥间隔物保留时间较长的患者,在进行转换TKA手术时,外科医生应考虑到大量骨丢失的情况。

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