Chen Fangfang, Liao Zhendong, Peng Daiyin, Han Lan
School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China
Ann Clin Lab Sci. 2019 Mar;49(2):161-170.
Platelet microparticles (PMPs) are released from the resting or activated platelet membrane, which includes a variety of proteins, mRNA, miRNA, lipids, and other substances. PMPs are involved in cell communication in vivo and are potential markers for multiple diseases. This narrative review focuses on the extraction, identification, and intercellular role of PMPs, with emphasis on the lesser known aspects of PMPs, namely, PMPs and complement systems, and their role in some diseases and disorders of women such as miscarriage and polycystic ovary syndrome, as well as the application of proteomics. For clinical purposes, we should first consider the importance of PMPs quantification and then what treatment should be given in response to increased quantities of PMPs as observed in many diseases. Currently, methods for quantification of PMPs are still in the experimental stages. Proteomics testing will expand biomarker discovery as well as future PMPs diagnostic and therapeutic applications.
血小板微粒（PMPs）由静息或活化的血小板膜释放，其包含多种蛋白质、信使核糖核酸（mRNA）、微小核糖核酸（miRNA）、脂质及其他物质。PMPs参与体内细胞通讯，是多种疾病的潜在标志物。本叙述性综述聚焦于PMPs的提取、鉴定及细胞间作用，重点关注PMPs鲜为人知的方面，即PMPs与补体系统，及其在流产和多囊卵巢综合征等一些女性疾病和病症中的作用，以及蛋白质组学的应用。出于临床目的，我们应首先考虑PMPs定量的重要性，然后针对许多疾病中观察到的PMPs数量增加应给予何种治疗。目前，PMPs的定量方法仍处于实验阶段。蛋白质组学检测将扩大生物标志物的发现以及未来PMPs的诊断和治疗应用。
