Wang Zhonghong, Wang Honggang, Shen Peng, Xie Rui
Department of Gastroenterology, Hongze District People's Hospital, Nanjing Medical University, Huai'an, China.
Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
Ann Clin Lab Sci. 2019 Mar;49(2):189-192.
Histone deacetylase 4 (HDAC4) is involved in the development of multiple types of cancers. In this study, we aimed to investigate the expression and clinical significance of HDAC4 in hepatocellular carcinoma (HCC).
49 patients with stage B HCC who underwent surgical resection were enrolled in this study. All patients were followed up with an observation time of 4.8 to 7 years. Immunohistochemistry was applied to investigate the expression level of HDAC4.
HDAC4 protein is over-expressed in HCC tissues compared with matched adjacent non-cancer tissues. Kaplan-Meier analysis shows that the positive expression of HDAC4 is associated with poor survival in these patients.
Our study shows that HDAC4 over-expression is important for the development of advanced HCC, which may serve as a useful prognostic biomarker and therapeutic target for this malignancy.
组蛋白去乙酰化酶4（HDAC4）参与多种类型癌症的发展。在本研究中，我们旨在调查HDAC4在肝细胞癌（HCC）中的表达及临床意义。
本研究纳入了49例行手术切除的B期HCC患者。所有患者均接受随访，观察时间为4.8至7年。应用免疫组织化学法检测HDAC4的表达水平。
与配对的癌旁非癌组织相比，HDAC4蛋白在HCC组织中过度表达。Kaplan-Meier分析显示，HDAC4的阳性表达与这些患者的不良生存相关。
我们的研究表明，HDAC4的过度表达对晚期HCC的发展很重要，这可能作为这种恶性肿瘤有用的预后生物标志物和治疗靶点。
