Association of Methylenetetrahydrofolate Reductase Polymorphism with Lower High-Density Lipoprotein Cholesterol Level.

BACKGROUND

Evidences about the relationship between methylenetetrahydrofolate reductase gene polymorphism and metabolic syndrome are controversial. The present study aimed to investigate if gene polymorphisms and are related to metabolic syndrome (MS).

METHODS

318 patients were enrolled and single nucleotide polymorphisms for and were genotyped. BMI, fasting blood glucose level (FBG), total cholesterol (TC), low-density lipoprotein (LDL), High-density lipoprotein (HDL) and triglycerides (TG) were measured.

RESULTS

In our study population, there were no significant differences for BMI, FBG, TC, LDL, TG or any component disease of MS between , wild type and variants. wild type had significant higher HDL level than variants (50.9±1.6 VS. 47.1±1.0, =0.036). Binary logistic regression analysis also showed that variants were significantly associated with lower HDL level (OR=0.963, 95%CI 0.93-0.99, =0.027). General linear model showed that there was no statistically significant interaction between and gene polymorphism on HDL level. So the reduction in HDL in variants was not due to its linkage disequilibrium with the polymorphism or an interaction between and genotypes.

CONCLUSION

Our study suggests that gene polymorphism is not related to any components of metabolic syndrome. variants were significantly associated with lower HDL level compared to wild type.