Mahesh Milan, Cheng Gang, Khalighi Koroush
Easton Cardiovascular Associates, Easton, PA, USA.
Moravian Academy, Bethlehem, PA, USA.
Ann Clin Lab Sci. 2019 Mar;49(2):232-236.
Evidences about the relationship between methylenetetrahydrofolate reductase gene polymorphism and metabolic syndrome are controversial. The present study aimed to investigate if gene polymorphisms and are related to metabolic syndrome (MS).
318 patients were enrolled and single nucleotide polymorphisms for and were genotyped. BMI, fasting blood glucose level (FBG), total cholesterol (TC), low-density lipoprotein (LDL), High-density lipoprotein (HDL) and triglycerides (TG) were measured.
In our study population, there were no significant differences for BMI, FBG, TC, LDL, TG or any component disease of MS between , wild type and variants. wild type had significant higher HDL level than variants (50.9±1.6 VS. 47.1±1.0, =0.036). Binary logistic regression analysis also showed that variants were significantly associated with lower HDL level (OR=0.963, 95%CI 0.93-0.99, =0.027). General linear model showed that there was no statistically significant interaction between and gene polymorphism on HDL level. So the reduction in HDL in variants was not due to its linkage disequilibrium with the polymorphism or an interaction between and genotypes.
Our study suggests that gene polymorphism is not related to any components of metabolic syndrome. variants were significantly associated with lower HDL level compared to wild type.
亚甲基四氢叶酸还原酶基因多态性与代谢综合征之间关系的证据存在争议。本研究旨在探讨该基因多态性是否与代谢综合征（MS）相关。
纳入318例患者，对该基因的单核苷酸多态性进行基因分型。测量体重指数（BMI）、空腹血糖水平（FBG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和甘油三酯（TG）。
在我们的研究人群中，该基因野生型和变异型在BMI、FBG、TC、LDL、TG或MS的任何组成疾病方面均无显著差异。该基因野生型的HDL水平显著高于变异型（50.9±1.6对47.1±1.0，P=0.036）。二元逻辑回归分析还显示，该基因变异型与较低的HDL水平显著相关（OR=0.963，95%CI 0.93 - 0.99，P=0.027）。一般线性模型显示，该基因与另一基因的多态性在HDL水平上无统计学显著的相互作用。因此，该基因变异型中HDL的降低并非由于其与另一基因多态性的连锁不平衡或两基因基因型之间的相互作用。
我们的研究表明，该基因多态性与代谢综合征的任何组成部分均无关。与该基因野生型相比，变异型与较低的HDL水平显著相关。
