Araki S, Ito H, Numa H, Okada K
Gan No Rinsho. 1987 Jan;33(1):54-9.
One-shot infusion of anticancer agents via the ligated internal iliac artery after urinary diversion was performed repeatedly in five patients with locally advanced bladder cancer in whom total cystectomy was contraindicated. Drugs infused were adriamycin and/or mitomycin C. Other combination treatments were undertaken before and after this strategy. They included radiation, oral chemotherapy and intravesical instillation of anticancer agents. Adverse reactions did not seem to be clinically significant. Complications were intractable fever, obstruction of the cannula, and prostration, resulting in interruption and discontinuity of this strategy within 11 weeks (in all cases). As a result, PR was achieved in two cases, MR in two, and PD in one according to Koyama-Saito's criteria. This strategy seemed to be promising and effective for locally advanced bladder cancer.
对五例局部晚期膀胱癌且禁忌行全膀胱切除术的患者，在尿流改道后经结扎的髂内动脉反复进行一次性抗癌药物输注。输注的药物为阿霉素和/或丝裂霉素C。在该治疗策略前后还采取了其他联合治疗。包括放疗、口服化疗和膀胱内抗癌药物灌注。不良反应在临床上似乎并不显著。并发症有顽固性发热、插管阻塞和虚脱，导致该治疗策略在11周内（所有病例）中断和停止。结果，根据小山-斋藤标准，两例达到部分缓解（PR），两例达到疾病稳定（MR），一例疾病进展（PD）。该治疗策略对局部晚期膀胱癌似乎有前景且有效。
