Müller-Deile K, Rupprath G, Vogt J
Monatsschr Kinderheilkd. 1986 Dec;134(12):854-7.
7 children and adolescents with pulmonary hypertension were examined with regard to the effect of Captopril as well on the pressure in the pulmonary artery and in the right ventricle as on the resistance in the systemic and pulmonary circulation and on the cardiac output. After initial application of Captopril 0.2 mg/kg body weight distinct oscillations of the data were measured, but with the exception of a small decrease of the mean pulmonary artery pressure (-8.5%) no determinable change was noticed. A decrease of the pulmonary artery resistance (-17%), the mean pulmonary artery pressure (-10%) and the right ventricular pressure (-3%) was found under continuous application of Captopril 0.3 mg/kg body weight daily for a period of 7 months. The cardiac output increased (+16%) and the systemic resistance decreased (-16%). The changes of data were not statistically significant. Captopril did not have a reliable therapeutic effect on the pressure and resistance in the pulmonary circulation in children and adolescents with pulmonary hypertension.
对7名患有肺动脉高压的儿童和青少年进行了检查，以研究卡托普利对肺动脉和右心室压力、体循环和肺循环阻力以及心输出量的影响。在最初应用0.2mg/kg体重的卡托普利后，测量到数据有明显波动，但除平均肺动脉压略有下降（-8.5%）外，未发现可确定的变化。在连续7个月每日应用0.3mg/kg体重的卡托普利后，发现肺动脉阻力下降（-17%）、平均肺动脉压下降（-10%）和右心室压力下降（-3%）。心输出量增加（+16%），体循环阻力下降（-16%）。数据变化无统计学意义。卡托普利对患有肺动脉高压的儿童和青少年的肺循环压力和阻力没有可靠的治疗效果。
